Pulsed Dye Laser-mediated Photodynamic Therapy is Less Effective than Conventional Photodynamic Therapy for Actinic Field Cancerization: A Randomized Half-side Comparative Study
Previous research presents pulsed dye laser-mediated photodynamic therapy as a promising alternative to conventional red-light photodynamic therapy. In this study, 60 patients with 2 or more actinic keratoses randomly received either of these treatments on each side of the head. A physician blinded...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2021-02-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3754
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| _version_ | 1798031377737711616 |
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| author | Vivian Lindholm Sari Pitkänen Marika Schröder Sonja Hahtola Helka Sahi Heini Halme Kirsi Isoherranen |
| author_facet | Vivian Lindholm Sari Pitkänen Marika Schröder Sonja Hahtola Helka Sahi Heini Halme Kirsi Isoherranen |
| author_sort | Vivian Lindholm |
| collection | DOAJ |
| description | Previous research presents pulsed dye laser-mediated photodynamic therapy as a promising alternative to conventional red-light photodynamic therapy. In this study, 60 patients with 2 or more actinic keratoses randomly received either of these treatments on each side of the head. A physician blinded to the treatment evaluated treatment response at 6 months for each lesion, as completely, partially or not healed. Significantly lower complete clearance rates (10.3% vs 44.9%) and lesion-specific complete clearance rates were found for pulsed dye laser-mediated photodynamic therapy (47.9%) vs conventional red-light photodynamic therapy (73.4%). Significantly lower pain scores were found for pulsed dye laser-mediated photodynamic therapy, with a mean numerical rating of 2.3, compared with 4.1 for conventional red-light photodynamic therapy. The study population had a mean of 7.9 lesions, and 78% of patients had been treated previously for actinic keratoses on the treatment area. To conclude, in a population with severe sun damage, pulsed dye laser-mediated photodynamic therapy seems less effective than conventional red-light photodynamic therapy. Pulsed dye laser-mediated photodynamic therapy may still be a treatment option for patients who are not compliant with conventional red-light photodynamic therapy. |
| first_indexed | 2024-04-11T19:56:30Z |
| format | Article |
| id | doaj.art-fda763a9aaf04d00a53cb9bd2b995e8f |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-04-11T19:56:30Z |
| publishDate | 2021-02-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-fda763a9aaf04d00a53cb9bd2b995e8f2022-12-22T04:06:02ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572021-02-011012adv0040410.2340/00015555-37545999Pulsed Dye Laser-mediated Photodynamic Therapy is Less Effective than Conventional Photodynamic Therapy for Actinic Field Cancerization: A Randomized Half-side Comparative StudyVivian Lindholm0Sari PitkänenMarika SchröderSonja HahtolaHelka SahiHeini HalmeKirsi Isoherranen Department of Dermatology and Allergology, Skin and Allergy Hospital, Helsinki University Hospital, Meilahdentie 2, FIN-00250 Helsinki, Finland. E-mail: vivian.lindholm@helsinki.fi. Previous research presents pulsed dye laser-mediated photodynamic therapy as a promising alternative to conventional red-light photodynamic therapy. In this study, 60 patients with 2 or more actinic keratoses randomly received either of these treatments on each side of the head. A physician blinded to the treatment evaluated treatment response at 6 months for each lesion, as completely, partially or not healed. Significantly lower complete clearance rates (10.3% vs 44.9%) and lesion-specific complete clearance rates were found for pulsed dye laser-mediated photodynamic therapy (47.9%) vs conventional red-light photodynamic therapy (73.4%). Significantly lower pain scores were found for pulsed dye laser-mediated photodynamic therapy, with a mean numerical rating of 2.3, compared with 4.1 for conventional red-light photodynamic therapy. The study population had a mean of 7.9 lesions, and 78% of patients had been treated previously for actinic keratoses on the treatment area. To conclude, in a population with severe sun damage, pulsed dye laser-mediated photodynamic therapy seems less effective than conventional red-light photodynamic therapy. Pulsed dye laser-mediated photodynamic therapy may still be a treatment option for patients who are not compliant with conventional red-light photodynamic therapy. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3754 actinic keratosis photochemotherapy lasers dye |
| spellingShingle | Vivian Lindholm Sari Pitkänen Marika Schröder Sonja Hahtola Helka Sahi Heini Halme Kirsi Isoherranen Pulsed Dye Laser-mediated Photodynamic Therapy is Less Effective than Conventional Photodynamic Therapy for Actinic Field Cancerization: A Randomized Half-side Comparative Study Acta Dermato-Venereologica actinic keratosis photochemotherapy lasers dye |
| title | Pulsed Dye Laser-mediated Photodynamic Therapy is Less Effective than Conventional Photodynamic Therapy for Actinic Field Cancerization: A Randomized Half-side Comparative Study |
| title_full | Pulsed Dye Laser-mediated Photodynamic Therapy is Less Effective than Conventional Photodynamic Therapy for Actinic Field Cancerization: A Randomized Half-side Comparative Study |
| title_fullStr | Pulsed Dye Laser-mediated Photodynamic Therapy is Less Effective than Conventional Photodynamic Therapy for Actinic Field Cancerization: A Randomized Half-side Comparative Study |
| title_full_unstemmed | Pulsed Dye Laser-mediated Photodynamic Therapy is Less Effective than Conventional Photodynamic Therapy for Actinic Field Cancerization: A Randomized Half-side Comparative Study |
| title_short | Pulsed Dye Laser-mediated Photodynamic Therapy is Less Effective than Conventional Photodynamic Therapy for Actinic Field Cancerization: A Randomized Half-side Comparative Study |
| title_sort | pulsed dye laser mediated photodynamic therapy is less effective than conventional photodynamic therapy for actinic field cancerization a randomized half side comparative study |
| topic | actinic keratosis photochemotherapy lasers dye |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3754
|
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