SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR
Hyperpolarized [1–13C]pyruvate is the leading metabolite used in the emerging field of hyperpolarization-enhanced MRI. Signal amplification by reversible exchange (SABRE) is a straight forward hyperpolarization method that has recently been shown to hyperpolarize [1–13C]pyruvate at low (microtesla a...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Journal of Magnetic Resonance Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666441024000049 |
| _version_ | 1797214850899771392 |
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| author | Adam Ortmeier Keilian MacCulloch Danila A. Barskiy Nicolas Kempf John Z Myers Rainer Körber Andrey N Pravdivtsev Kai Buckenmaier Thomas Theis |
| author_facet | Adam Ortmeier Keilian MacCulloch Danila A. Barskiy Nicolas Kempf John Z Myers Rainer Körber Andrey N Pravdivtsev Kai Buckenmaier Thomas Theis |
| author_sort | Adam Ortmeier |
| collection | DOAJ |
| description | Hyperpolarized [1–13C]pyruvate is the leading metabolite used in the emerging field of hyperpolarization-enhanced MRI. Signal amplification by reversible exchange (SABRE) is a straight forward hyperpolarization method that has recently been shown to hyperpolarize [1–13C]pyruvate at low (microtesla and below) magnetic fields. Here, we show that commercial optical magnetometers with Rb-vapor media can be used to readily monitor the build-up and decay of the hyperpolarized MR signal. In addition, we measure ZULF-NMR spectra in various conditions, ranging from a J-coupling-dominated regime transitioning into a Zeeman-dominated regime when going from a sub-nT field to a µT field. The experimentally acquired spectra are matched well by numerical simulations. |
| first_indexed | 2024-04-24T11:20:44Z |
| format | Article |
| id | doaj.art-fda78a4d071e4c2d873b29bbb5608567 |
| institution | Directory Open Access Journal |
| issn | 2666-4410 |
| language | English |
| last_indexed | 2024-04-24T11:20:44Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Magnetic Resonance Open |
| spelling | doaj.art-fda78a4d071e4c2d873b29bbb56085672024-04-11T04:41:58ZengElsevierJournal of Magnetic Resonance Open2666-44102024-06-0119100149SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMRAdam Ortmeier0Keilian MacCulloch1Danila A. Barskiy2Nicolas Kempf3John Z Myers4Rainer Körber5Andrey N Pravdivtsev6Kai Buckenmaier7Thomas Theis8Department of Chemistry, North Carolina State University, Raleigh 27606, NC, United StatesDepartment of Chemistry, North Carolina State University, Raleigh 27606, NC, United StatesJohannes Gutenberg Universität Mainz, Mainz 55128, Germany,; Helmholtz-Institut Mainz, Mainz 55128, Germany; Helmholtzzentrum für Schwerionenforschung, Darmstadt 64291, GermanyDepartment of High Field Magnetic Resonance, Max Planck Institute for Cybernetics, Tübingen 72076, GermanyPhysikalisch-Technische Bundesanstalt, Abbestrasse 2-12, Berlin 10587, GermanyPhysikalisch-Technische Bundesanstalt, Abbestrasse 2-12, Berlin 10587, GermanySection Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein and Kiel University, Am Botanischen Garten 14, Kiel 24118, GermanyDepartment of High Field Magnetic Resonance, Max Planck Institute for Cybernetics, Tübingen 72076, GermanyDepartment of Chemistry, North Carolina State University, Raleigh 27606, NC, United States; Department of High Field Magnetic Resonance, Max Planck Institute for Cybernetics, Tübingen 72076, Germany; Department of Physics, North Carolina State University, North Carolina 27606, Raleigh, United States; Corresponding author.Hyperpolarized [1–13C]pyruvate is the leading metabolite used in the emerging field of hyperpolarization-enhanced MRI. Signal amplification by reversible exchange (SABRE) is a straight forward hyperpolarization method that has recently been shown to hyperpolarize [1–13C]pyruvate at low (microtesla and below) magnetic fields. Here, we show that commercial optical magnetometers with Rb-vapor media can be used to readily monitor the build-up and decay of the hyperpolarized MR signal. In addition, we measure ZULF-NMR spectra in various conditions, ranging from a J-coupling-dominated regime transitioning into a Zeeman-dominated regime when going from a sub-nT field to a µT field. The experimentally acquired spectra are matched well by numerical simulations.http://www.sciencedirect.com/science/article/pii/S2666441024000049HyperpolarizationSABREParahydrogenZULF-NMRPyruvate |
| spellingShingle | Adam Ortmeier Keilian MacCulloch Danila A. Barskiy Nicolas Kempf John Z Myers Rainer Körber Andrey N Pravdivtsev Kai Buckenmaier Thomas Theis SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR Journal of Magnetic Resonance Open Hyperpolarization SABRE Parahydrogen ZULF-NMR Pyruvate |
| title | SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR |
| title_full | SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR |
| title_fullStr | SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR |
| title_full_unstemmed | SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR |
| title_short | SABRE-hyperpolarization dynamics of [1-13C]pyruvate monitored by in situ zero- to ultra-low field NMR |
| title_sort | sabre hyperpolarization dynamics of 1 13c pyruvate monitored by in situ zero to ultra low field nmr |
| topic | Hyperpolarization SABRE Parahydrogen ZULF-NMR Pyruvate |
| url | http://www.sciencedirect.com/science/article/pii/S2666441024000049 |
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