The effect of pomalidumide on inflammatory factors and Antioxidant-Prooxidant balance in Rat Model of Ovalbumin-induced Asthma
Background and Aim: Allergic asthma is an inflammatory disease of the respiratory system which causes an increase in inflammatory factors such as IL-2,IL-4,IL-5, lymphocytes and eosinophils. These factors can increase the level of free radicals and oxidants. Pomalidumide, an anti-inflammatory drug t...
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| Format: | Article |
| Language: | fas |
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Kurdistan University of Medical Sciences
2019-02-01
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| Series: | مجله علمی دانشگاه علوم پزشکی کردستان |
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| Online Access: | http://sjku.muk.ac.ir/article-۱-۴۲۴۵-fa.html |
| _version_ | 1811249774666448896 |
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| author | Majid Ghaderi Dr Shahrbanoo Oryan Namdar Yousofvand Akram Eidi |
| author_facet | Majid Ghaderi Dr Shahrbanoo Oryan Namdar Yousofvand Akram Eidi |
| author_sort | Majid Ghaderi Dr |
| collection | DOAJ |
| description | Background and Aim: Allergic asthma is an inflammatory disease of the respiratory system which causes an increase in inflammatory factors such as IL-2,IL-4,IL-5, lymphocytes and eosinophils. These factors can increase the level of free radicals and oxidants. Pomalidumide, an anti-inflammatory drug that has stronger effects than its analogues, can significantly reduce inflammatory factors. The aim of this study was to evaluate the effect of pomalidumide on inflammatory factors and pro-oxidant antioxidant balance in the rat model of ovalbumin-induced asthma.
Material and Methods: Male rats were divided into 5 groups (n=8): normal saline, ovalbumin+normal saline, ovalbumin+dexamethasone, ovalbumin+pomalidimide (0.4 0.8 mg/kg, ip). We used ELISA method to determine the level of inflammatory factors. We measured pro-oxidant-antioxidant balance (PAB) for assessment of blood oxidant level.
Results: We found significant decrease in the levels of inflammatory factors in the pomalidumide group. This decrease was more significant in the group that received pomalidumide 0.8 mg/kg, ip.
Conclusion: The results of this study showed that pomalidomide prevented the pro-oxidant antioxidant balance shift towards increasing oxidant factors in the asthmatic rats. Also it prevented increase in inflammatory factors including IL-2, IL-4,IL-5, lymphocytes and eosinophils in the ovalbumin-induced asthma rat model. |
| first_indexed | 2024-04-12T15:52:27Z |
| format | Article |
| id | doaj.art-fda7cee6e42e4f42bbc9cfaa5b4868a0 |
| institution | Directory Open Access Journal |
| issn | 2345-4040 1560-652X |
| language | fas |
| last_indexed | 2024-04-12T15:52:27Z |
| publishDate | 2019-02-01 |
| publisher | Kurdistan University of Medical Sciences |
| record_format | Article |
| series | مجله علمی دانشگاه علوم پزشکی کردستان |
| spelling | doaj.art-fda7cee6e42e4f42bbc9cfaa5b4868a02022-12-22T03:26:28ZfasKurdistan University of Medical Sciencesمجله علمی دانشگاه علوم پزشکی کردستان2345-40401560-652X2019-02-012361124The effect of pomalidumide on inflammatory factors and Antioxidant-Prooxidant balance in Rat Model of Ovalbumin-induced AsthmaMajid Ghaderi Dr0 Shahrbanoo Oryan1 Namdar Yousofvand2 Akram Eidi3Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran , sh_oryan@yahoo.comDepartment of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran Department of Biology, Faculty of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Background and Aim: Allergic asthma is an inflammatory disease of the respiratory system which causes an increase in inflammatory factors such as IL-2,IL-4,IL-5, lymphocytes and eosinophils. These factors can increase the level of free radicals and oxidants. Pomalidumide, an anti-inflammatory drug that has stronger effects than its analogues, can significantly reduce inflammatory factors. The aim of this study was to evaluate the effect of pomalidumide on inflammatory factors and pro-oxidant antioxidant balance in the rat model of ovalbumin-induced asthma. Material and Methods: Male rats were divided into 5 groups (n=8): normal saline, ovalbumin+normal saline, ovalbumin+dexamethasone, ovalbumin+pomalidimide (0.4 0.8 mg/kg, ip). We used ELISA method to determine the level of inflammatory factors. We measured pro-oxidant-antioxidant balance (PAB) for assessment of blood oxidant level. Results: We found significant decrease in the levels of inflammatory factors in the pomalidumide group. This decrease was more significant in the group that received pomalidumide 0.8 mg/kg, ip. Conclusion: The results of this study showed that pomalidomide prevented the pro-oxidant antioxidant balance shift towards increasing oxidant factors in the asthmatic rats. Also it prevented increase in inflammatory factors including IL-2, IL-4,IL-5, lymphocytes and eosinophils in the ovalbumin-induced asthma rat model.http://sjku.muk.ac.ir/article-۱-۴۲۴۵-fa.htmlPomalidomideAsthmaprooxidant-antioxidantInflammation. |
| spellingShingle | Majid Ghaderi Dr Shahrbanoo Oryan Namdar Yousofvand Akram Eidi The effect of pomalidumide on inflammatory factors and Antioxidant-Prooxidant balance in Rat Model of Ovalbumin-induced Asthma مجله علمی دانشگاه علوم پزشکی کردستان Pomalidomide Asthma prooxidant-antioxidant Inflammation. |
| title | The effect of pomalidumide on inflammatory factors and Antioxidant-Prooxidant balance in Rat Model of Ovalbumin-induced Asthma |
| title_full | The effect of pomalidumide on inflammatory factors and Antioxidant-Prooxidant balance in Rat Model of Ovalbumin-induced Asthma |
| title_fullStr | The effect of pomalidumide on inflammatory factors and Antioxidant-Prooxidant balance in Rat Model of Ovalbumin-induced Asthma |
| title_full_unstemmed | The effect of pomalidumide on inflammatory factors and Antioxidant-Prooxidant balance in Rat Model of Ovalbumin-induced Asthma |
| title_short | The effect of pomalidumide on inflammatory factors and Antioxidant-Prooxidant balance in Rat Model of Ovalbumin-induced Asthma |
| title_sort | effect of pomalidumide on inflammatory factors and antioxidant prooxidant balance in rat model of ovalbumin induced asthma |
| topic | Pomalidomide Asthma prooxidant-antioxidant Inflammation. |
| url | http://sjku.muk.ac.ir/article-۱-۴۲۴۵-fa.html |
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