The Generation of Human iPSC Lines from Three Individuals with Dravet Syndrome and Characterization of Neural Differentiation Markers in iPSC-Derived Ventral Forebrain Organoid Model

The Generation of Human iPSC Lines from Three Individuals with Dravet Syndrome and Characterization of Neural Differentiation Markers in iPSC-Derived Ventral Forebrain Organoid Model

Dravet syndrome (DRVT) is a rare form of neurodevelopmental disorder with a high risk of sudden unexpected death in epilepsy (SUDEP), caused mainly (>80% cases) by mutations in the <i>SCN1A</i> gene, coding the Nav1.1 protein (alfa-subunit of voltage-sensitive sodium channel). Mutatio...

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Bibliographic Details
Main Authors: Valery Zayat, Zuzanna Kuczynska, Michal Liput, Erkan Metin, Sylwia Rzonca-Niewczas, Marta Smyk, Tomasz Mazurczak, Alicja Goszczanska-Ciuchta, Pawel Leszczynski, Dorota Hoffman-Zacharska, Leonora Buzanska
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
<i>SCN1A</i>-related disorders
Dravet syndrome
Panayiotopoulos syndrome
Nav1.1 haploinsufficiency
stem cell reprogramming
organoids
Online Access:https://www.mdpi.com/2073-4409/12/2/339

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