Prolonged vs intermittent intravenous infusion of β-lactam antibiotics for patients with sepsis: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis

Prolonged vs intermittent intravenous infusion of β-lactam antibiotics for patients with sepsis: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis

Abstract Background The prolonged β-lactam antibiotics infusion has been an attractive strategy in severe infections, because it provides a more stable free drug concentration and a longer duration of free drug concentration above the minimum inhibitory concentration (MIC). We conducted this systema...

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Bibliographic Details
Main Authors: Xiaoming Li, Yi Long, Guixin Wu, Rui Li, Mingming Zhou, Aiting He, Zhengying Jiang
Format: Article
Language:English
Published: SpringerOpen 2023-12-01
Series:Annals of Intensive Care
Subjects:
Beta-lactams
Drug administration schedule
Sepsis
Septic shock
Meta-analysis
Online Access:https://doi.org/10.1186/s13613-023-01222-w

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