Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects

Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects

Summary: The clinical response to immune checkpoint blockade (ICB) correlates with tumor-infiltrating cytolytic T lymphocytes (CTLs) prior to treatment. However, many of these inflamed tumors resist ICB through unknown mechanisms. We show that tumors with transcription elongation deficiencies (TEdef...

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Bibliographic Details
Main Authors:	Vishnu Modur, Belal Muhammad, Jun-Qi Yang, Yi Zheng, Kakajan Komurov, Fukun Guo
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Series:	Cell Reports
Subjects:	CP: Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124723003753

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