Oxidation of 2-Hydroxynevirapine, a Phenolic Metabolite of the Anti-HIV Drug Nevirapine: Evidence for an Unusual Pyridine Ring Contraction

Oxidation of 2-Hydroxynevirapine, a Phenolic Metabolite of the Anti-HIV Drug Nevirapine: Evidence for an Unusual Pyridine Ring Contraction

Nevirapine (NVP) is an anti-HIV drug associated with severe hepatotoxicity and skin rashes, which raises concerns about its chronic administration. There is increasing evidence that metabolic activation to reactive electrophiles capable of reacting with bionucleophiles is likely to be involved in th...

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Bibliographic Details
Main Authors: Frederick A. Beland, João L. Ferreira da Silva, Pedro P. Santos, Shrika G. Harjivan, David A. Novais, Muna Sidarus, Alexandra M. M. Antunes, M. Matilde Marques
Format: Article
Language:English
Published: MDPI AG 2012-03-01
Series:Molecules
Subjects:
anti-HIV drug
nevirapine
oxidation
pyridine ring contraction
Online Access:http://www.mdpi.com/1420-3049/17/3/2616/

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