Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review
Drug induced hyperthermia is a rare presentation which can rapidly lead to gross metabolic abnormality and death. These presentations are further complicated by the wide range of potentially causative agents. We present a case of rigidity and hyperthermia, following overdose of an initially unknown...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2018-07-01
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| Series: | Bulletin of Emergency and Trauma |
| Subjects: | |
| Online Access: | http://beat.sums.ac.ir/article_44443_28941780eb3bb925f27a8cbf19bc1d91.pdf |
| _version_ | 1818258150582648832 |
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| author | Rose Dean-Paccagnella Matthew Creed Mahendra Kakollu Suresh Gopala Pillai |
| author_facet | Rose Dean-Paccagnella Matthew Creed Mahendra Kakollu Suresh Gopala Pillai |
| author_sort | Rose Dean-Paccagnella |
| collection | DOAJ |
| description | Drug induced hyperthermia is a rare presentation which can rapidly lead to gross metabolic abnormality and death. These presentations are further complicated by the wide range of potentially causative agents. We present a case of rigidity and hyperthermia, following overdose of an initially unknown substance leading to challenging management decisions in the Emergency Department. This case was later identified as Serotonin Syndrome. The patient presented with trismus which was managed with rapid sequence induction of anaesthesia to allow airway protection. On extubation a significant degree of laryngeal oedema complicated weaning, a possible complication of Serotonin Syndrome not previously described in the literature. We discuss the pathophysiology of Serotonin Syndrome, important differentials and practical considerations in managing hypertonicity of unknown origin in a young person. |
| first_indexed | 2024-12-12T17:54:58Z |
| format | Article |
| id | doaj.art-fdac4a8f007c4d6ea4490a29accb902b |
| institution | Directory Open Access Journal |
| issn | 2322-2522 2322-3960 |
| language | English |
| last_indexed | 2024-12-12T17:54:58Z |
| publishDate | 2018-07-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Bulletin of Emergency and Trauma |
| spelling | doaj.art-fdac4a8f007c4d6ea4490a29accb902b2022-12-22T00:16:44ZengShiraz University of Medical SciencesBulletin of Emergency and Trauma2322-25222322-39602018-07-016Issue 324925244443Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature ReviewRose Dean-Paccagnella0Matthew Creed1Mahendra Kakollu2Suresh Gopala Pillai3Abertawe Bro Morgannwg University Health BoardAbertawe Bro Morgannwg University Health BoardAbertawe Bro Morgannwg University Health BoardAbertawe Bro Morgannwg University Health BoardDrug induced hyperthermia is a rare presentation which can rapidly lead to gross metabolic abnormality and death. These presentations are further complicated by the wide range of potentially causative agents. We present a case of rigidity and hyperthermia, following overdose of an initially unknown substance leading to challenging management decisions in the Emergency Department. This case was later identified as Serotonin Syndrome. The patient presented with trismus which was managed with rapid sequence induction of anaesthesia to allow airway protection. On extubation a significant degree of laryngeal oedema complicated weaning, a possible complication of Serotonin Syndrome not previously described in the literature. We discuss the pathophysiology of Serotonin Syndrome, important differentials and practical considerations in managing hypertonicity of unknown origin in a young person.http://beat.sums.ac.ir/article_44443_28941780eb3bb925f27a8cbf19bc1d91.pdfSerotonin syndromeOverdoseHyperthermiaHypertonicity |
| spellingShingle | Rose Dean-Paccagnella Matthew Creed Mahendra Kakollu Suresh Gopala Pillai Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review Bulletin of Emergency and Trauma Serotonin syndrome Overdose Hyperthermia Hypertonicity |
| title | Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review |
| title_full | Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review |
| title_fullStr | Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review |
| title_full_unstemmed | Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review |
| title_short | Hyperthermia and Rigidity Following Overdose of an Unknown Drug; A Case Report and Literature Review |
| title_sort | hyperthermia and rigidity following overdose of an unknown drug a case report and literature review |
| topic | Serotonin syndrome Overdose Hyperthermia Hypertonicity |
| url | http://beat.sums.ac.ir/article_44443_28941780eb3bb925f27a8cbf19bc1d91.pdf |
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