Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis
Background: Trauma is a leading cause of death and disability. Patients with trauma undergoing invasive mechanical ventilation (IMV) are at risk for ventilator-associated events (VAEs) potentially associated with a longer duration of IMV and increased stay in the intensive care unit (ICU). Methods:...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/1/176 |
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| author | Emanuele Russo Marta Velia Antonini Andrea Sica Cristian Dell’Amore Costanza Martino Emiliano Gamberini Luca Bissoni Alessandro Circelli Giuliano Bolondi Domenico Pietro Santonastaso Francesco Cristini Luigi Raumer Fausto Catena Vanni Agnoletti |
| author_facet | Emanuele Russo Marta Velia Antonini Andrea Sica Cristian Dell’Amore Costanza Martino Emiliano Gamberini Luca Bissoni Alessandro Circelli Giuliano Bolondi Domenico Pietro Santonastaso Francesco Cristini Luigi Raumer Fausto Catena Vanni Agnoletti |
| author_sort | Emanuele Russo |
| collection | DOAJ |
| description | Background: Trauma is a leading cause of death and disability. Patients with trauma undergoing invasive mechanical ventilation (IMV) are at risk for ventilator-associated events (VAEs) potentially associated with a longer duration of IMV and increased stay in the intensive care unit (ICU). Methods: We conducted a retrospective cohort study aimed to evaluate the incidence of infection-related ventilator-associated complications (IVACs), possible ventilator-associated pneumonia (PVAP), and their characteristics among patients experiencing severe trauma that required ICU admission and IMV for at least four days. We also determined pathogens implicated in PVAP episodes and characterized the use of antimicrobial therapy. Results: In total, 88 adult patients were included in the main analysis. In this study, we observed that 29.5% of patients developed a respiratory infection during ICU stay. Among them, five patients (19.2%) suffered from respiratory infections due to multi-drug resistant bacteria. Patients who developed IVAC/PVAP presented lower total GCS (median value, 7; (IQR, 9) vs. 12.5, (IQR, 8); <i>p</i> = 0.068) than those who did not develop IVAC/PVAP. Conclusions: We observed that less than one-third of trauma patients fulfilling criteria for ventilator associated events developed a respiratory infection during the ICU stay. |
| first_indexed | 2024-03-09T13:47:43Z |
| format | Article |
| id | doaj.art-fdadaea8f69c41a09fc2bfb308ff44ab |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-09T13:47:43Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-fdadaea8f69c41a09fc2bfb308ff44ab2023-11-30T20:56:49ZengMDPI AGAntibiotics2079-63822023-01-0112117610.3390/antibiotics12010176Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective AnalysisEmanuele Russo0Marta Velia Antonini1Andrea Sica2Cristian Dell’Amore3Costanza Martino4Emiliano Gamberini5Luca Bissoni6Alessandro Circelli7Giuliano Bolondi8Domenico Pietro Santonastaso9Francesco Cristini10Luigi Raumer11Fausto Catena12Vanni Agnoletti13Anesthesia and Intensive Care Unit, Bufalini Hospital, AUSL Romagna, 47521 Cesena, ItalyAnesthesia and Intensive Care Unit, Bufalini Hospital, AUSL Romagna, 47521 Cesena, ItalyAnesthesia and Intensive Care Unit, Bufalini Hospital, AUSL Romagna, 47521 Cesena, ItalyAnesthesia and Intensive Care Unit, Bufalini Hospital, AUSL Romagna, 47521 Cesena, ItalyAnesthesia and Intensive Care Unit, Umberto I Hospital, AUSL Romagna, 48022 Lugo, ItalyAnesthesia and Intensive Care Unit, Infermi Hospital, AUSL della Romagna, 47923 Rimini, ItalyAnesthesia and Intensive Care Unit, Bufalini Hospital, AUSL Romagna, 47521 Cesena, ItalyAnesthesia and Intensive Care Unit, Bufalini Hospital, AUSL Romagna, 47521 Cesena, ItalyAnesthesia and Intensive Care Unit, Bufalini Hospital, AUSL Romagna, 47521 Cesena, ItalyAnesthesia and Intensive Care Unit, Bufalini Hospital, AUSL Romagna, 47521 Cesena, ItalyInfectious Diseases Unit, Forlì-Cesena Hospitals, AUSL Romagna, 47121 Forlì-Cesena, ItalyInfectious Diseases Unit, Forlì-Cesena Hospitals, AUSL Romagna, 47121 Forlì-Cesena, ItalyDepartment of Emergency Surgery and Trauma, Bufalini Hospital, AUSL Romagna, 47521 Cesena, ItalyAnesthesia and Intensive Care Unit, Bufalini Hospital, AUSL Romagna, 47521 Cesena, ItalyBackground: Trauma is a leading cause of death and disability. Patients with trauma undergoing invasive mechanical ventilation (IMV) are at risk for ventilator-associated events (VAEs) potentially associated with a longer duration of IMV and increased stay in the intensive care unit (ICU). Methods: We conducted a retrospective cohort study aimed to evaluate the incidence of infection-related ventilator-associated complications (IVACs), possible ventilator-associated pneumonia (PVAP), and their characteristics among patients experiencing severe trauma that required ICU admission and IMV for at least four days. We also determined pathogens implicated in PVAP episodes and characterized the use of antimicrobial therapy. Results: In total, 88 adult patients were included in the main analysis. In this study, we observed that 29.5% of patients developed a respiratory infection during ICU stay. Among them, five patients (19.2%) suffered from respiratory infections due to multi-drug resistant bacteria. Patients who developed IVAC/PVAP presented lower total GCS (median value, 7; (IQR, 9) vs. 12.5, (IQR, 8); <i>p</i> = 0.068) than those who did not develop IVAC/PVAP. Conclusions: We observed that less than one-third of trauma patients fulfilling criteria for ventilator associated events developed a respiratory infection during the ICU stay.https://www.mdpi.com/2079-6382/12/1/176ventilator associated pneumoniatraumatraumatic brain injurymechanical ventilatorsantimicrobial stewardshipanti-infective agents |
| spellingShingle | Emanuele Russo Marta Velia Antonini Andrea Sica Cristian Dell’Amore Costanza Martino Emiliano Gamberini Luca Bissoni Alessandro Circelli Giuliano Bolondi Domenico Pietro Santonastaso Francesco Cristini Luigi Raumer Fausto Catena Vanni Agnoletti Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis Antibiotics ventilator associated pneumonia trauma traumatic brain injury mechanical ventilators antimicrobial stewardship anti-infective agents |
| title | Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
| title_full | Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
| title_fullStr | Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
| title_full_unstemmed | Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
| title_short | Infection-Related Ventilator-Associated Complications in Critically Ill Patients with Trauma: A Retrospective Analysis |
| title_sort | infection related ventilator associated complications in critically ill patients with trauma a retrospective analysis |
| topic | ventilator associated pneumonia trauma traumatic brain injury mechanical ventilators antimicrobial stewardship anti-infective agents |
| url | https://www.mdpi.com/2079-6382/12/1/176 |
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