The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysis
Introduction By applying on two-sample Mendelian randomization and systematic review and meta-analysis we investigated the association between caffeine and coffee intake with prevalent CKD and markers of renal function. Material and methods For the individual data analysis we analysed the NHANES da...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-12-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.archivesofmedicalscience.com/The-association-between-coffee-and-caffeine-consumption-and-renal-function-insight,144905,0,2.html |
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| author | Mohsen Mazidi Dimitri P. Mikhailidis Abbas Dehghan Jacek Jóźwiak Adrian Covic Naveed Sattar Maciej Banach on behalf of the Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP) |
| author_facet | Mohsen Mazidi Dimitri P. Mikhailidis Abbas Dehghan Jacek Jóźwiak Adrian Covic Naveed Sattar Maciej Banach on behalf of the Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP) |
| author_sort | Mohsen Mazidi |
| collection | DOAJ |
| description | Introduction
By applying on two-sample Mendelian randomization and systematic review and meta-analysis we investigated the association between caffeine and coffee intake with prevalent CKD and markers of renal function.
Material and methods
For the individual data analysis we analysed the NHANES data on renal function markers and caffeine intake. MR was implemented by using summary-level data from the largest ever GWAS conducted on coffee intake (N=91,462) and kidney function.
Results
Finally, we included the data of 18,436 participants, 6.9% had prevalent CKD (based on eGFR). Caffeine intake for general population was 131.1±1.1 mg. The percentage of participants with CKD, by caffeine quartile was 16.6% in the first (lowest) quartile, 13.9% in the second, 12.2% in the third and 11.0% in the top quartile (p 0.234). In fully adjusted logistic regression models, there was no significant difference in chances of CKD prevalence (p-trend=0.745). In the same line, results of MR showed no impact of coffee intake on CKD (IVW=β: -0.0191, SE: 0.069, p=0.781), on eGFR (overall= IVW= β: -0.0005, SE: 0.005, p=0.926) both in diabetic (IVW= β: -0.006, SE: 0.009, p=0.478), and non-diabetic patients (IVW= β: -6.772, SE: 0.006, p=0.991). Results from the meta-analysis indicted that coffee consumption was not significantly associated with CKD (OR: 0.85, 95%CI 0.71-1.02, p=0.090, n=6 studies, I2=0.32).
Conclusions
By implementing on different strategies, we have highlighted no significant association between coffee consumption with renal function and chance of CKD. |
| first_indexed | 2024-03-09T10:46:02Z |
| format | Article |
| id | doaj.art-fdaebdad86aa4ffd8ee798bfa7f02394 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:46:02Z |
| publishDate | 2021-12-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-fdaebdad86aa4ffd8ee798bfa7f023942023-12-01T10:02:33ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512021-12-0118490091110.5114/aoms/144905144905The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysisMohsen Mazidi0https://orcid.org/0000-0003-3059-229XDimitri P. Mikhailidis1https://orcid.org/0000-0002-5802-0528Abbas Dehghan2https://orcid.org/0000-0001-6403-016XJacek Jóźwiak3https://orcid.org/0000-0002-2645-7274Adrian Covic4https://orcid.org/0000-0002-9985-2486Naveed Sattar5https://orcid.org/0000-0002-1604-2593Maciej Banach6https://orcid.org/0000-0001-6690-6874on behalf of the Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP)Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital, Strand, London, UK, United KingdomDepartment of Clinical Biochemistry, Royal Free Campus, University College London Medical School, University College London (UCL), London, UK, United KingdomMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom, United KingdomDepartment of Family Medicine and Public Health, Institute of Medicine, University of Opole, Opole, Poland, United KingdomDepartment of Nephrology, "Dr. C. I. Parhon" Clinical Hospital Iasi, Iasi, Romania, RomaniaInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK, United KingdomCardiovascular Research Centre, University of Zielona Gora, Zielona Gora, PolandIntroduction By applying on two-sample Mendelian randomization and systematic review and meta-analysis we investigated the association between caffeine and coffee intake with prevalent CKD and markers of renal function. Material and methods For the individual data analysis we analysed the NHANES data on renal function markers and caffeine intake. MR was implemented by using summary-level data from the largest ever GWAS conducted on coffee intake (N=91,462) and kidney function. Results Finally, we included the data of 18,436 participants, 6.9% had prevalent CKD (based on eGFR). Caffeine intake for general population was 131.1±1.1 mg. The percentage of participants with CKD, by caffeine quartile was 16.6% in the first (lowest) quartile, 13.9% in the second, 12.2% in the third and 11.0% in the top quartile (p 0.234). In fully adjusted logistic regression models, there was no significant difference in chances of CKD prevalence (p-trend=0.745). In the same line, results of MR showed no impact of coffee intake on CKD (IVW=β: -0.0191, SE: 0.069, p=0.781), on eGFR (overall= IVW= β: -0.0005, SE: 0.005, p=0.926) both in diabetic (IVW= β: -0.006, SE: 0.009, p=0.478), and non-diabetic patients (IVW= β: -6.772, SE: 0.006, p=0.991). Results from the meta-analysis indicted that coffee consumption was not significantly associated with CKD (OR: 0.85, 95%CI 0.71-1.02, p=0.090, n=6 studies, I2=0.32). Conclusions By implementing on different strategies, we have highlighted no significant association between coffee consumption with renal function and chance of CKD.https://www.archivesofmedicalscience.com/The-association-between-coffee-and-caffeine-consumption-and-renal-function-insight,144905,0,2.htmlcoffeechronic kidney diseasemendelian randomizationnhanessystematic review |
| spellingShingle | Mohsen Mazidi Dimitri P. Mikhailidis Abbas Dehghan Jacek Jóźwiak Adrian Covic Naveed Sattar Maciej Banach on behalf of the Lipid and Blood Pressure Meta-analysis Collaboration (LBPMC) Group and the International Lipid Expert Panel (ILEP) The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysis Archives of Medical Science coffee chronic kidney disease mendelian randomization nhanes systematic review |
| title | The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysis |
| title_full | The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysis |
| title_fullStr | The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysis |
| title_full_unstemmed | The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysis |
| title_short | The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysis |
| title_sort | association between coffee and caffeine consumption and renal function insight from individual level data mendelian randomization and meta analysis |
| topic | coffee chronic kidney disease mendelian randomization nhanes systematic review |
| url | https://www.archivesofmedicalscience.com/The-association-between-coffee-and-caffeine-consumption-and-renal-function-insight,144905,0,2.html |
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