Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells
We review the evolution and development of organ of Corti hair cells with a focus on their molecular differences from vestibular hair cells. Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and generate the correct arrangement of different ha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2018.00252/full |
| _version_ | 1818494072388583424 |
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| author | Karen L. Elliott Bernd Fritzsch Jeremy S. Duncan |
| author_facet | Karen L. Elliott Bernd Fritzsch Jeremy S. Duncan |
| author_sort | Karen L. Elliott |
| collection | DOAJ |
| description | We review the evolution and development of organ of Corti hair cells with a focus on their molecular differences from vestibular hair cells. Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and generate the correct arrangement of different hair cell types, orientation of stereocilia, and the delayed loss of the kinocilium that are all essential for hearing, while avoiding driving hair cells toward a vestibular fate. Highlighting the differences from vestibular organs and defining what is known about the regulation of these differences will help focus future research directions toward successful restoration of an organ of Corti following long-term hair cell loss. |
| first_indexed | 2024-12-10T18:01:53Z |
| format | Article |
| id | doaj.art-fdaf4da5c221423ba89e09f0cd9cedae |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-10T18:01:53Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-fdaf4da5c221423ba89e09f0cd9cedae2022-12-22T01:38:46ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022018-08-011210.3389/fncel.2018.00252376162Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair CellsKaren L. Elliott0Bernd Fritzsch1Jeremy S. Duncan2Department of Biology, University of Iowa, Iowa City, IA, United StatesDepartment of Biology, University of Iowa, Iowa City, IA, United StatesDepartment of Biological Sciences, Western Michigan University, Kalamazoo, MI, United StatesWe review the evolution and development of organ of Corti hair cells with a focus on their molecular differences from vestibular hair cells. Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and generate the correct arrangement of different hair cell types, orientation of stereocilia, and the delayed loss of the kinocilium that are all essential for hearing, while avoiding driving hair cells toward a vestibular fate. Highlighting the differences from vestibular organs and defining what is known about the regulation of these differences will help focus future research directions toward successful restoration of an organ of Corti following long-term hair cell loss.https://www.frontiersin.org/article/10.3389/fncel.2018.00252/fullorgan of Corti evolutionhair cell planar cell polarityhair cell kinocilium lossMET channel mutation effectsPCP effects on sensory neurons |
| spellingShingle | Karen L. Elliott Bernd Fritzsch Jeremy S. Duncan Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells Frontiers in Cellular Neuroscience organ of Corti evolution hair cell planar cell polarity hair cell kinocilium loss MET channel mutation effects PCP effects on sensory neurons |
| title | Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells |
| title_full | Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells |
| title_fullStr | Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells |
| title_full_unstemmed | Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells |
| title_short | Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells |
| title_sort | evolutionary and developmental biology provide insights into the regeneration of organ of corti hair cells |
| topic | organ of Corti evolution hair cell planar cell polarity hair cell kinocilium loss MET channel mutation effects PCP effects on sensory neurons |
| url | https://www.frontiersin.org/article/10.3389/fncel.2018.00252/full |
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