N-terminal pro-B-type natriuretic peptide for the prognostic prediction of severe enterovirus 71-associated hand, foot, and mouth disease
Objective: The aim of this study was to determine whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) can predict impending brainstem encephalitis, pulmonary edema, pulmonary hemorrhage, cardiopulmonary failure, and death in children with severe enterovirus 71 (EV71)-associated hand, foot,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971216311985 |
| _version_ | 1818515329541734400 |
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| author | Jun Qiu Xiulan Lu Pingping Liu Xinping Zhang Chao Zuo Zhenghui Xiao |
| author_facet | Jun Qiu Xiulan Lu Pingping Liu Xinping Zhang Chao Zuo Zhenghui Xiao |
| author_sort | Jun Qiu |
| collection | DOAJ |
| description | Objective: The aim of this study was to determine whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) can predict impending brainstem encephalitis, pulmonary edema, pulmonary hemorrhage, cardiopulmonary failure, and death in children with severe enterovirus 71 (EV71)-associated hand, foot, and mouth disease (HFMD).
Methods: Plasma NT-proBNP levels of 282 children with severe EV71-associated HFMD were measured.
Results: NT-proBNP levels were significantly higher in patients with elevated blood glucose (>7.8 mmol/l) and increased white blood cell counts (>14 × 109/l). HFMD patients who had no complications had significantly lower NT-proBNP values than patients who died or had complications (p < 0.05). The area under the receiver operating characteristic (ROC) curve was 0.73, 0.87, 0.91, 0.93, and 0.92 to discriminate between patients with and without brainstem encephalitis, pulmonary edema, pulmonary hemorrhage, circulatory failure, and death, respectively, using NT-proBNP. An NT-proBNP cut-off value of ≥1300 pg/ml demonstrated a high sensitivity (85.00%) and specificity (93.51%) for predicting death in critical HFMD patients. Children with severe EV71-associated HFMD and NT-proBNP measurements ≥1300 pg/ml had significantly worse overall survival compared to those with levels <1300 pg/ml (p < 0.05).
Conclusions: NT-proBNP levels may be able to predict complications and mortality in children with severe EV71-associated HFMD disease in the intensive care unit. Serum NT-proBNP values ≥1300 pg/ml on admission could be indicative of circulatory failure and increased mortality. |
| first_indexed | 2024-12-11T00:27:32Z |
| format | Article |
| id | doaj.art-fdb00e7e909f41f89faaabf515e170f1 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 1878-3511 |
| language | English |
| last_indexed | 2024-12-11T00:27:32Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-fdb00e7e909f41f89faaabf515e170f12022-12-22T01:27:29ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112017-01-0154C647110.1016/j.ijid.2016.10.014N-terminal pro-B-type natriuretic peptide for the prognostic prediction of severe enterovirus 71-associated hand, foot, and mouth diseaseJun QiuXiulan LuPingping LiuXinping ZhangChao ZuoZhenghui XiaoObjective: The aim of this study was to determine whether N-terminal pro-B-type natriuretic peptide (NT-proBNP) can predict impending brainstem encephalitis, pulmonary edema, pulmonary hemorrhage, cardiopulmonary failure, and death in children with severe enterovirus 71 (EV71)-associated hand, foot, and mouth disease (HFMD). Methods: Plasma NT-proBNP levels of 282 children with severe EV71-associated HFMD were measured. Results: NT-proBNP levels were significantly higher in patients with elevated blood glucose (>7.8 mmol/l) and increased white blood cell counts (>14 × 109/l). HFMD patients who had no complications had significantly lower NT-proBNP values than patients who died or had complications (p < 0.05). The area under the receiver operating characteristic (ROC) curve was 0.73, 0.87, 0.91, 0.93, and 0.92 to discriminate between patients with and without brainstem encephalitis, pulmonary edema, pulmonary hemorrhage, circulatory failure, and death, respectively, using NT-proBNP. An NT-proBNP cut-off value of ≥1300 pg/ml demonstrated a high sensitivity (85.00%) and specificity (93.51%) for predicting death in critical HFMD patients. Children with severe EV71-associated HFMD and NT-proBNP measurements ≥1300 pg/ml had significantly worse overall survival compared to those with levels <1300 pg/ml (p < 0.05). Conclusions: NT-proBNP levels may be able to predict complications and mortality in children with severe EV71-associated HFMD disease in the intensive care unit. Serum NT-proBNP values ≥1300 pg/ml on admission could be indicative of circulatory failure and increased mortality.http://www.sciencedirect.com/science/article/pii/S1201971216311985N-terminal pro-B-type natriuretic peptideHandfootand mouth diseaseCardiopulmonary failure |
| spellingShingle | Jun Qiu Xiulan Lu Pingping Liu Xinping Zhang Chao Zuo Zhenghui Xiao N-terminal pro-B-type natriuretic peptide for the prognostic prediction of severe enterovirus 71-associated hand, foot, and mouth disease International Journal of Infectious Diseases N-terminal pro-B-type natriuretic peptide Hand foot and mouth disease Cardiopulmonary failure |
| title | N-terminal pro-B-type natriuretic peptide for the prognostic prediction of severe enterovirus 71-associated hand, foot, and mouth disease |
| title_full | N-terminal pro-B-type natriuretic peptide for the prognostic prediction of severe enterovirus 71-associated hand, foot, and mouth disease |
| title_fullStr | N-terminal pro-B-type natriuretic peptide for the prognostic prediction of severe enterovirus 71-associated hand, foot, and mouth disease |
| title_full_unstemmed | N-terminal pro-B-type natriuretic peptide for the prognostic prediction of severe enterovirus 71-associated hand, foot, and mouth disease |
| title_short | N-terminal pro-B-type natriuretic peptide for the prognostic prediction of severe enterovirus 71-associated hand, foot, and mouth disease |
| title_sort | n terminal pro b type natriuretic peptide for the prognostic prediction of severe enterovirus 71 associated hand foot and mouth disease |
| topic | N-terminal pro-B-type natriuretic peptide Hand foot and mouth disease Cardiopulmonary failure |
| url | http://www.sciencedirect.com/science/article/pii/S1201971216311985 |
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