| Summary: | <i>Solanum betaceum</i> Cav., commonly known as tamarillo or Brazilian tomato, belongs to the Solanaceae family. Its fruit is used in traditional medicine and food crops due to its health benefits. Despite the numerous studies involving the fruit, there is no scientific knowledge about the tamarillo tree leaves. In this work, the phenolic profile of aqueous extract obtained from <i>S. betaceum</i> leaves was unveiled for the first time. Five hydroxycinnamic phenolic acids were identified and quantified, including 3-<i>O</i>-caffeoylquinic acid, 4-<i>O</i>-caffeoylquinic acid, chlorogenic acid, caffeic acid and rosmarinic acid. While the extract displayed no effect on α-amylase, the extract inhibited the activity of α-glucosidase (IC<sub>50</sub> = 1617 mg/mL), and it was particularly effective for human aldose reductase (IC<sub>50</sub> = 0.236 mg/mL): a key enzyme in glucose metabolism. Moreover, the extract exhibited interesting antioxidant properties, such as a potent capacity to intercept the in vitro-generated reactive species O<sub>2</sub><sup>•−</sup> (IC<sub>50</sub> = 0.119 mg/mL) and <sup>•</sup>NO (IC<sub>50</sub> = 0.299 mg/mL), as well as to inhibit the first stages of lipid peroxidation (IC<sub>50</sub> = 0.080 mg/mL). This study highlights the biological potential of <i>S. betaceum</i> leaves. The scarcity of research on this natural resource underscores the need for additional studies in order to fully explore its antidiabetic properties and to promote the value of a species currently at risk of extinction.
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