Cardiac Function Evaluation after SARS-CoV-2 mRNA Vaccination in Children and Adolescents: A Prospective Speckle-Tracking Echocardiography Study
Background: Possible cardiac impairment after SARS-CoV-2 mRNA vaccination is a common driver of parental vaccine hesitancy. We performed a comprehensive echocardiographic evaluation of biventricular function in vaccinated children with or without previous COVID-19 compared to healthy controls. Metho...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/8/1348 |
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| author | Jolanda Sabatino Costanza Di Chiara Daria Lauretta Jennifer Fumanelli Greta Luana D’Ascoli Daniele Donà Sandra Cozzani Andrea Oletto Carlo Giaquinto Giovanni Di Salvo |
| author_facet | Jolanda Sabatino Costanza Di Chiara Daria Lauretta Jennifer Fumanelli Greta Luana D’Ascoli Daniele Donà Sandra Cozzani Andrea Oletto Carlo Giaquinto Giovanni Di Salvo |
| author_sort | Jolanda Sabatino |
| collection | DOAJ |
| description | Background: Possible cardiac impairment after SARS-CoV-2 mRNA vaccination is a common driver of parental vaccine hesitancy. We performed a comprehensive echocardiographic evaluation of biventricular function in vaccinated children with or without previous COVID-19 compared to healthy controls. Methods: We conducted a single-center, prospective, case–control study enrolling children and adolescents aged 5–18 years attending the pediatric clinic of the University Hospital of Padua from April to June 2022. Three months after receiving the primary mRNA vaccination or booster dose, the patients underwent a cardiac assessment, including standard echocardiography and speckle-tracking echocardiography (STE). A pre-pandemic historical cohort of age- and gender-matched healthy children were used as a control. Results: A total of 39 post-VACCINE cases (24, 61% female), mean age 12.6 ± 2.6 years (range 8–17), were enrolled in the study. Ninety percent (N = 35) of patients were previously healthy. No differences in left ventricular diameters, left ventricular ejection fraction (LVEF), and tricuspid annular plane systolic excursion (TAPSE) were observed between cases and controls. Global longitudinal strain (GLS) was in the normal range in all individuals, with no differences between post-VACCINE cases and controls (−21.7 ± 2.3% vs. 21.2 ± 1.8%; <i>p</i> = 0.338). However, GLS was found to be slightly but significantly reduced in post-VACCINE children with a previous COVID-19 compared to naïve-vaccinated individuals (post-VACCINE+COVID-19: −19.9 ± 1.1% vs. post-VACCINE-only: −22.0 ± 2.3%; <i>p</i> = 0.002). Conclusions: We did not observe an impairment in GLS or in other indices of LV structure or function after mRNA COVID-19 vaccination. |
| first_indexed | 2024-03-10T23:32:12Z |
| format | Article |
| id | doaj.art-fdb10c85e58d4560b09db0c4ad6a53fe |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T23:32:12Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-fdb10c85e58d4560b09db0c4ad6a53fe2023-11-19T03:17:53ZengMDPI AGVaccines2076-393X2023-08-01118134810.3390/vaccines11081348Cardiac Function Evaluation after SARS-CoV-2 mRNA Vaccination in Children and Adolescents: A Prospective Speckle-Tracking Echocardiography StudyJolanda Sabatino0Costanza Di Chiara1Daria Lauretta2Jennifer Fumanelli3Greta Luana D’Ascoli4Daniele Donà5Sandra Cozzani6Andrea Oletto7Carlo Giaquinto8Giovanni Di Salvo9Division of Pediatric Cardiology, Department for Women’s and Children’s Health, University of Padua, 35128 Padova, ItalyDivision of Pediatric Infectious Diseases, Department for Women’s and Children’s Health, University of Padua, 35128 Padova, ItalyDivision of Pediatric Cardiology, Department for Women’s and Children’s Health, University of Padua, 35128 Padova, ItalyDivision of Pediatric Cardiology, Department for Women’s and Children’s Health, University of Padua, 35128 Padova, ItalyDivision of Pediatric Cardiology, Department for Women’s and Children’s Health, University of Padua, 35128 Padova, ItalyDivision of Pediatric Infectious Diseases, Department for Women’s and Children’s Health, University of Padua, 35128 Padova, ItalyDivision of Pediatric Infectious Diseases, Department for Women’s and Children’s Health, University of Padua, 35128 Padova, ItalyPenta–Child Health Research, 35127 Padua, ItalyDivision of Pediatric Infectious Diseases, Department for Women’s and Children’s Health, University of Padua, 35128 Padova, ItalyDivision of Pediatric Cardiology, Department for Women’s and Children’s Health, University of Padua, 35128 Padova, ItalyBackground: Possible cardiac impairment after SARS-CoV-2 mRNA vaccination is a common driver of parental vaccine hesitancy. We performed a comprehensive echocardiographic evaluation of biventricular function in vaccinated children with or without previous COVID-19 compared to healthy controls. Methods: We conducted a single-center, prospective, case–control study enrolling children and adolescents aged 5–18 years attending the pediatric clinic of the University Hospital of Padua from April to June 2022. Three months after receiving the primary mRNA vaccination or booster dose, the patients underwent a cardiac assessment, including standard echocardiography and speckle-tracking echocardiography (STE). A pre-pandemic historical cohort of age- and gender-matched healthy children were used as a control. Results: A total of 39 post-VACCINE cases (24, 61% female), mean age 12.6 ± 2.6 years (range 8–17), were enrolled in the study. Ninety percent (N = 35) of patients were previously healthy. No differences in left ventricular diameters, left ventricular ejection fraction (LVEF), and tricuspid annular plane systolic excursion (TAPSE) were observed between cases and controls. Global longitudinal strain (GLS) was in the normal range in all individuals, with no differences between post-VACCINE cases and controls (−21.7 ± 2.3% vs. 21.2 ± 1.8%; <i>p</i> = 0.338). However, GLS was found to be slightly but significantly reduced in post-VACCINE children with a previous COVID-19 compared to naïve-vaccinated individuals (post-VACCINE+COVID-19: −19.9 ± 1.1% vs. post-VACCINE-only: −22.0 ± 2.3%; <i>p</i> = 0.002). Conclusions: We did not observe an impairment in GLS or in other indices of LV structure or function after mRNA COVID-19 vaccination.https://www.mdpi.com/2076-393X/11/8/1348COVID-19 vaccinationspeckle-tracking echocardiographychildrenmRNA vaccinesechocardiography |
| spellingShingle | Jolanda Sabatino Costanza Di Chiara Daria Lauretta Jennifer Fumanelli Greta Luana D’Ascoli Daniele Donà Sandra Cozzani Andrea Oletto Carlo Giaquinto Giovanni Di Salvo Cardiac Function Evaluation after SARS-CoV-2 mRNA Vaccination in Children and Adolescents: A Prospective Speckle-Tracking Echocardiography Study Vaccines COVID-19 vaccination speckle-tracking echocardiography children mRNA vaccines echocardiography |
| title | Cardiac Function Evaluation after SARS-CoV-2 mRNA Vaccination in Children and Adolescents: A Prospective Speckle-Tracking Echocardiography Study |
| title_full | Cardiac Function Evaluation after SARS-CoV-2 mRNA Vaccination in Children and Adolescents: A Prospective Speckle-Tracking Echocardiography Study |
| title_fullStr | Cardiac Function Evaluation after SARS-CoV-2 mRNA Vaccination in Children and Adolescents: A Prospective Speckle-Tracking Echocardiography Study |
| title_full_unstemmed | Cardiac Function Evaluation after SARS-CoV-2 mRNA Vaccination in Children and Adolescents: A Prospective Speckle-Tracking Echocardiography Study |
| title_short | Cardiac Function Evaluation after SARS-CoV-2 mRNA Vaccination in Children and Adolescents: A Prospective Speckle-Tracking Echocardiography Study |
| title_sort | cardiac function evaluation after sars cov 2 mrna vaccination in children and adolescents a prospective speckle tracking echocardiography study |
| topic | COVID-19 vaccination speckle-tracking echocardiography children mRNA vaccines echocardiography |
| url | https://www.mdpi.com/2076-393X/11/8/1348 |
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