Rat Hepatocytes Mitigate Cadmium Toxicity by Forming Annular Gap Junctions and Degrading Them via Endosome–Lysosome Pathway

Rat Hepatocytes Mitigate Cadmium Toxicity by Forming Annular Gap Junctions and Degrading Them via Endosome–Lysosome Pathway

Gap junction protein connexin 43 (Cx43) plays a critical role in gap junction communication in rat hepatocytes. However, those located between hepatocytes are easily internalized following exposure to poisons. Herein, we investigated the potential of buffalo rat liver 3A (BRL 3A) cells to generate a...

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Bibliographic Details
Main Authors: Junzhao Yuan, Xiaoqian Huang, Yumeng Zhao, Jianhong Gu, Yan Yuan, Zongping Liu, Hui Zou, Jianchun Bian
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
annular gap junction
cadmium
connexin 43
endosome
lysosome
microtubule
Online Access:https://www.mdpi.com/1422-0067/23/24/15607

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