Current outlook on radionuclide delivery systems: from design consideration to translation into clinics
Abstract Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-019-0524-9 |
| _version_ | 1797999649902034944 |
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| author | Oleksii O. Peltek Albert R. Muslimov Mikhail V. Zyuzin Alexander S. Timin |
| author_facet | Oleksii O. Peltek Albert R. Muslimov Mikhail V. Zyuzin Alexander S. Timin |
| author_sort | Oleksii O. Peltek |
| collection | DOAJ |
| description | Abstract Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide a comprehensive review on the most relevant aspects in radionuclide delivery using the most employed carrier systems, including, (i) monoclonal antibodies and their fragments, (ii) organic and (iii) inorganic nanoparticles, and (iv) microspheres. This review offers an extensive analysis of radionuclide delivery systems, the approaches of their modification and radiolabeling strategies with the further prospects of their implementation in multimodal imaging and disease curing. Finally, the comparative outlook on the carriers and radionuclide choice, as well as on the targeting efficiency of the developed systems is discussed. |
| first_indexed | 2024-04-11T11:08:02Z |
| format | Article |
| id | doaj.art-fdb63534da104dfe9ffc7e7c92c89e3e |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T11:08:02Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-fdb63534da104dfe9ffc7e7c92c89e3e2022-12-22T04:28:15ZengBMCJournal of Nanobiotechnology1477-31552019-08-0117113410.1186/s12951-019-0524-9Current outlook on radionuclide delivery systems: from design consideration to translation into clinicsOleksii O. Peltek0Albert R. Muslimov1Mikhail V. Zyuzin2Alexander S. Timin3Russian Research Center of Radiology and Surgical Technologies (RRCRST) of Ministry of Public HealthRussian Research Center of Radiology and Surgical Technologies (RRCRST) of Ministry of Public HealthFaculty of Physics and Engineering, ITMO UniversityRussian Research Center of Radiology and Surgical Technologies (RRCRST) of Ministry of Public HealthAbstract Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical studies depends on the choice of a sufficient delivery platform. Herein, we provide a comprehensive review on the most relevant aspects in radionuclide delivery using the most employed carrier systems, including, (i) monoclonal antibodies and their fragments, (ii) organic and (iii) inorganic nanoparticles, and (iv) microspheres. This review offers an extensive analysis of radionuclide delivery systems, the approaches of their modification and radiolabeling strategies with the further prospects of their implementation in multimodal imaging and disease curing. Finally, the comparative outlook on the carriers and radionuclide choice, as well as on the targeting efficiency of the developed systems is discussed.http://link.springer.com/article/10.1186/s12951-019-0524-9Nuclear medicineDiagnostic and therapeutic radionuclidesDrug carrier systemsMonoclonal antibodiesNanoparticlesMicrospheres |
| spellingShingle | Oleksii O. Peltek Albert R. Muslimov Mikhail V. Zyuzin Alexander S. Timin Current outlook on radionuclide delivery systems: from design consideration to translation into clinics Journal of Nanobiotechnology Nuclear medicine Diagnostic and therapeutic radionuclides Drug carrier systems Monoclonal antibodies Nanoparticles Microspheres |
| title | Current outlook on radionuclide delivery systems: from design consideration to translation into clinics |
| title_full | Current outlook on radionuclide delivery systems: from design consideration to translation into clinics |
| title_fullStr | Current outlook on radionuclide delivery systems: from design consideration to translation into clinics |
| title_full_unstemmed | Current outlook on radionuclide delivery systems: from design consideration to translation into clinics |
| title_short | Current outlook on radionuclide delivery systems: from design consideration to translation into clinics |
| title_sort | current outlook on radionuclide delivery systems from design consideration to translation into clinics |
| topic | Nuclear medicine Diagnostic and therapeutic radionuclides Drug carrier systems Monoclonal antibodies Nanoparticles Microspheres |
| url | http://link.springer.com/article/10.1186/s12951-019-0524-9 |
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