Dehydration affects drug transport over nasal mucosa
Formulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that muc...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2019.1650848 |
| _version_ | 1818336214462234624 |
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| author | Abdullah Ali Marie Wahlgren Birgitta Rembratt-Svensson Ameena Daftani Peter Falkman Per Wollmer Johan Engblom |
| author_facet | Abdullah Ali Marie Wahlgren Birgitta Rembratt-Svensson Ameena Daftani Peter Falkman Per Wollmer Johan Engblom |
| author_sort | Abdullah Ali |
| collection | DOAJ |
| description | Formulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that mucoadhesion achieved through water sorption could also be a constraint for drug absorption via the nasal route. The effect of altering water activity of the vehicle on Xylometazoline HCl and 51Cr-EDTA uptake was studied separately ex vivo using flow through diffusion cells and excised porcine mucosa. We have shown that a modest increase in the water gradient over mucosa induces a substantial decrease in drug uptake for both Xylometazoline HCl and 51Cr-EDTA. A similar result was obtained when comparing two different vehicles on the market; Nasoferm® (Nordic Drugs, Sweden) and BLOX4® (Bioglan, Sweden). Mucoadhesion based on water sorption can slow down drug uptake in the nasal cavity. However, a clinical study is required to determine whether prolonged duration of the vehicle in situ or preventing dehydration of the mucosa is the most important factor for improving bioavailability. |
| first_indexed | 2024-12-13T14:35:46Z |
| format | Article |
| id | doaj.art-fdb7716a8b6942c0abded99ae8f42ed8 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-13T14:35:46Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-fdb7716a8b6942c0abded99ae8f42ed82022-12-21T23:41:44ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642019-01-0126183184010.1080/10717544.2019.16508481650848Dehydration affects drug transport over nasal mucosaAbdullah Ali0Marie Wahlgren1Birgitta Rembratt-Svensson2Ameena Daftani3Peter Falkman4Per Wollmer5Johan Engblom6Malmö UniversityLund UniversityBioglan ABMalmö UniversityMalmö UniversityLund UniversityMalmö UniversityFormulations for nasal drug delivery often rely on water sorption to adhere to the mucosa, which also causes a higher water gradient over the tissue and subsequent dehydration. The primary aim of this study was therefore to evaluate mucosal response to dehydration and resolve the hypothesis that mucoadhesion achieved through water sorption could also be a constraint for drug absorption via the nasal route. The effect of altering water activity of the vehicle on Xylometazoline HCl and 51Cr-EDTA uptake was studied separately ex vivo using flow through diffusion cells and excised porcine mucosa. We have shown that a modest increase in the water gradient over mucosa induces a substantial decrease in drug uptake for both Xylometazoline HCl and 51Cr-EDTA. A similar result was obtained when comparing two different vehicles on the market; Nasoferm® (Nordic Drugs, Sweden) and BLOX4® (Bioglan, Sweden). Mucoadhesion based on water sorption can slow down drug uptake in the nasal cavity. However, a clinical study is required to determine whether prolonged duration of the vehicle in situ or preventing dehydration of the mucosa is the most important factor for improving bioavailability.http://dx.doi.org/10.1080/10717544.2019.1650848mucoadhesionnasal drug deliverydehydrationwater activitydrug transport |
| spellingShingle | Abdullah Ali Marie Wahlgren Birgitta Rembratt-Svensson Ameena Daftani Peter Falkman Per Wollmer Johan Engblom Dehydration affects drug transport over nasal mucosa Drug Delivery mucoadhesion nasal drug delivery dehydration water activity drug transport |
| title | Dehydration affects drug transport over nasal mucosa |
| title_full | Dehydration affects drug transport over nasal mucosa |
| title_fullStr | Dehydration affects drug transport over nasal mucosa |
| title_full_unstemmed | Dehydration affects drug transport over nasal mucosa |
| title_short | Dehydration affects drug transport over nasal mucosa |
| title_sort | dehydration affects drug transport over nasal mucosa |
| topic | mucoadhesion nasal drug delivery dehydration water activity drug transport |
| url | http://dx.doi.org/10.1080/10717544.2019.1650848 |
| work_keys_str_mv | AT abdullahali dehydrationaffectsdrugtransportovernasalmucosa AT mariewahlgren dehydrationaffectsdrugtransportovernasalmucosa AT birgittarembrattsvensson dehydrationaffectsdrugtransportovernasalmucosa AT ameenadaftani dehydrationaffectsdrugtransportovernasalmucosa AT peterfalkman dehydrationaffectsdrugtransportovernasalmucosa AT perwollmer dehydrationaffectsdrugtransportovernasalmucosa AT johanengblom dehydrationaffectsdrugtransportovernasalmucosa |