Coronary heart disease treatment: old principles and new horizons
Basing on literature data, the authors demonstrate the link between heart rate (HR) and mortality in coronary heart disease (CHD) and arterial hypertension. HR reduction strategy as an important therapeutic target in CHD management is proposed. Ant-ischemic and antianginal mechanisms of a novel agen...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2007-02-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1171 |
| _version_ | 1797882781445914624 |
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| author | Yu. A. Vasyuk E. L. Shkol’nik |
| author_facet | Yu. A. Vasyuk E. L. Shkol’nik |
| author_sort | Yu. A. Vasyuk |
| collection | DOAJ |
| description | Basing on literature data, the authors demonstrate the link between heart rate (HR) and mortality in coronary heart disease (CHD) and arterial hypertension. HR reduction strategy as an important therapeutic target in CHD management is proposed. Ant-ischemic and antianginal mechanisms of a novel agent, ivabradine, selectively reducing HR due to sinus node f-channel ion current inhibition, are discussed. Clinical evidence of ivabradine effectiveness in stable angina, comparing to other modern antianginal medications, is presented. Potential benefits of ivabradine therapy in HR reduction-requiring clinical situations are discussed. |
| first_indexed | 2024-04-10T03:40:15Z |
| format | Article |
| id | doaj.art-fdb8d9a06a45411c86e316fad75f1449 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:40:15Z |
| publishDate | 2007-02-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-fdb8d9a06a45411c86e316fad75f14492023-03-13T07:23:13Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252007-02-01619298883Coronary heart disease treatment: old principles and new horizonsYu. A. Vasyuk0E. L. Shkol’nik1Московский государственный медико-стоматологический университет, МоскваМосковский государственный медико-стоматологический университет, МоскваBasing on literature data, the authors demonstrate the link between heart rate (HR) and mortality in coronary heart disease (CHD) and arterial hypertension. HR reduction strategy as an important therapeutic target in CHD management is proposed. Ant-ischemic and antianginal mechanisms of a novel agent, ivabradine, selectively reducing HR due to sinus node f-channel ion current inhibition, are discussed. Clinical evidence of ivabradine effectiveness in stable angina, comparing to other modern antianginal medications, is presented. Potential benefits of ivabradine therapy in HR reduction-requiring clinical situations are discussed.https://cardiovascular.elpub.ru/jour/article/view/1171стабильная стенокардияивабрадинif-токи |
| spellingShingle | Yu. A. Vasyuk E. L. Shkol’nik Coronary heart disease treatment: old principles and new horizons Кардиоваскулярная терапия и профилактика стабильная стенокардия ивабрадин if-токи |
| title | Coronary heart disease treatment: old principles and new horizons |
| title_full | Coronary heart disease treatment: old principles and new horizons |
| title_fullStr | Coronary heart disease treatment: old principles and new horizons |
| title_full_unstemmed | Coronary heart disease treatment: old principles and new horizons |
| title_short | Coronary heart disease treatment: old principles and new horizons |
| title_sort | coronary heart disease treatment old principles and new horizons |
| topic | стабильная стенокардия ивабрадин if-токи |
| url | https://cardiovascular.elpub.ru/jour/article/view/1171 |
| work_keys_str_mv | AT yuavasyuk coronaryheartdiseasetreatmentoldprinciplesandnewhorizons AT elshkolnik coronaryheartdiseasetreatmentoldprinciplesandnewhorizons |