Impact of Different Modules of 21-Gene Assay in Early Breast Cancer Patients
BackgroundThe 21-gene assay recurrence score (RS) provides additional information on recurrence risk of breast cancer patients and prediction of chemotherapy benefit. Previous studies that examined the contribution of the individual genes and gene modules of RS were conducted mostly in postmenopausa...
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| Format: | Article |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.759338/full |
| _version_ | 1831717443422126080 |
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| author | Mengdi Chen Mengdi Chen Deyue Liu Weilin Chen Weilin Chen Weiguo Chen Kunwei Shen Jiayi Wu Li Zhu |
| author_facet | Mengdi Chen Mengdi Chen Deyue Liu Weilin Chen Weilin Chen Weiguo Chen Kunwei Shen Jiayi Wu Li Zhu |
| author_sort | Mengdi Chen |
| collection | DOAJ |
| description | BackgroundThe 21-gene assay recurrence score (RS) provides additional information on recurrence risk of breast cancer patients and prediction of chemotherapy benefit. Previous studies that examined the contribution of the individual genes and gene modules of RS were conducted mostly in postmenopausal patients. We aimed to evaluate the gene modules of RS in patients of different ages.MethodsA total of 1,078 estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer patients diagnosed between January 2009 and March 2017 from Shanghai Jiao Tong University Breast Cancer Data Base were included. All patients were divided into three subgroups: Group A, ≤40 years and premenopausal (n = 97); Group B, >40 years and premenopausal (n = 284); Group C, postmenopausal (n = 697). The estrogen, proliferation, invasion, and HER2 module scores from RS were used to characterize the respective molecular features. Spearman correlation and analysis of the variance tests were conducted for RS and its constituent modules.ResultsIn patients >40 years, RS had a strong negative correlation with its estrogen module (ρ = −0.76 and −0.79 in Groups B and C) and a weak positive correlation with its invasion module (ρ = 0.29 and 0.25 in Groups B and C). The proliferation module mostly contributed to the variance in young patients (37.3%) while the ER module contributed most in old patients (54.1% and 53.4% in Groups B and C). In the genetic high-risk (RS >25) group, the proliferation module was the leading driver in all patients (ρ = 0.38, 0.53, and 0.52 in Groups A, B, and C) while the estrogen module had a weaker correlation with RS. The impact of ER module on RS was stronger in clinical low-risk patients while the effect of the proliferation module was stronger in clinical high-risk patients. The association between the RS and estrogen module was weaker among younger patients, especially in genetic low-risk patients.ConclusionsRS was primarily driven by the estrogen module regardless of age, but the proliferation module had a stronger impact on RS in younger patients. The impact of modules varied in patients with different genetic and clinical risks. |
| first_indexed | 2024-12-21T00:59:31Z |
| format | Article |
| id | doaj.art-fdbf47ac5a68448384ff7c9fb8452129 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-21T00:59:31Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-fdbf47ac5a68448384ff7c9fb84521292022-12-21T19:21:14ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-11-011210.3389/fendo.2021.759338759338Impact of Different Modules of 21-Gene Assay in Early Breast Cancer PatientsMengdi Chen0Mengdi Chen1Deyue Liu2Weilin Chen3Weilin Chen4Weiguo Chen5Kunwei Shen6Jiayi Wu7Li Zhu8Department of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Thyroid and Breast Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School, Shanghai, ChinaDepartment of Thyroid and Breast Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School, Shanghai, ChinaDepartment of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Thyroid and Breast Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School, Shanghai, ChinaDepartment of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of General Surgery, Comprehensive Breast Health Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Thyroid and Breast Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School, Shanghai, ChinaBackgroundThe 21-gene assay recurrence score (RS) provides additional information on recurrence risk of breast cancer patients and prediction of chemotherapy benefit. Previous studies that examined the contribution of the individual genes and gene modules of RS were conducted mostly in postmenopausal patients. We aimed to evaluate the gene modules of RS in patients of different ages.MethodsA total of 1,078 estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer patients diagnosed between January 2009 and March 2017 from Shanghai Jiao Tong University Breast Cancer Data Base were included. All patients were divided into three subgroups: Group A, ≤40 years and premenopausal (n = 97); Group B, >40 years and premenopausal (n = 284); Group C, postmenopausal (n = 697). The estrogen, proliferation, invasion, and HER2 module scores from RS were used to characterize the respective molecular features. Spearman correlation and analysis of the variance tests were conducted for RS and its constituent modules.ResultsIn patients >40 years, RS had a strong negative correlation with its estrogen module (ρ = −0.76 and −0.79 in Groups B and C) and a weak positive correlation with its invasion module (ρ = 0.29 and 0.25 in Groups B and C). The proliferation module mostly contributed to the variance in young patients (37.3%) while the ER module contributed most in old patients (54.1% and 53.4% in Groups B and C). In the genetic high-risk (RS >25) group, the proliferation module was the leading driver in all patients (ρ = 0.38, 0.53, and 0.52 in Groups A, B, and C) while the estrogen module had a weaker correlation with RS. The impact of ER module on RS was stronger in clinical low-risk patients while the effect of the proliferation module was stronger in clinical high-risk patients. The association between the RS and estrogen module was weaker among younger patients, especially in genetic low-risk patients.ConclusionsRS was primarily driven by the estrogen module regardless of age, but the proliferation module had a stronger impact on RS in younger patients. The impact of modules varied in patients with different genetic and clinical risks.https://www.frontiersin.org/articles/10.3389/fendo.2021.759338/fullbreast cancerhormone receptor positiverecurrence score21-gene assayadjuvant therapies |
| spellingShingle | Mengdi Chen Mengdi Chen Deyue Liu Weilin Chen Weilin Chen Weiguo Chen Kunwei Shen Jiayi Wu Li Zhu Impact of Different Modules of 21-Gene Assay in Early Breast Cancer Patients Frontiers in Endocrinology breast cancer hormone receptor positive recurrence score 21-gene assay adjuvant therapies |
| title | Impact of Different Modules of 21-Gene Assay in Early Breast Cancer Patients |
| title_full | Impact of Different Modules of 21-Gene Assay in Early Breast Cancer Patients |
| title_fullStr | Impact of Different Modules of 21-Gene Assay in Early Breast Cancer Patients |
| title_full_unstemmed | Impact of Different Modules of 21-Gene Assay in Early Breast Cancer Patients |
| title_short | Impact of Different Modules of 21-Gene Assay in Early Breast Cancer Patients |
| title_sort | impact of different modules of 21 gene assay in early breast cancer patients |
| topic | breast cancer hormone receptor positive recurrence score 21-gene assay adjuvant therapies |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.759338/full |
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