A rare case of vasculitis in cystic fibrosis: A clinical case
Introduction: Cystic fibrosis is known to cause serious complications, such as recurrent pulmonary infections, pancreatic insufficiency, and other symptoms related to exocrine gland dysfunction. A rare manifestation of the disease is discussed in this case of a 24-year-old female diagnosed with cyst...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
|
| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007123000114 |
| _version_ | 1797870633071149056 |
|---|---|
| author | Sabrina Nasreddine Mitchelle Issa Zeina Aoun Bacha |
| author_facet | Sabrina Nasreddine Mitchelle Issa Zeina Aoun Bacha |
| author_sort | Sabrina Nasreddine |
| collection | DOAJ |
| description | Introduction: Cystic fibrosis is known to cause serious complications, such as recurrent pulmonary infections, pancreatic insufficiency, and other symptoms related to exocrine gland dysfunction. A rare manifestation of the disease is discussed in this case of a 24-year-old female diagnosed with cystic fibrosis, a purpuric rash was documented during pulmonary infection flares. Skin biopsy shows a leukocytoclastic vasculitis eruption along with infection. Treatment options are limited and not well established. Our patient received a treatment based on colchicine 1mg per day with a total response. The patient was observed during two consecutive pulmonary infection flares separated by a few months, and a total remission without recurrence was found. Conclusion: Considering its efficacy and safety, further scientific research about colchicine and vasculitis in cystic fibrosis should be aimed at in order to define a strong consensus between the disease and this treatment option. |
| first_indexed | 2024-04-10T00:30:27Z |
| format | Article |
| id | doaj.art-fdc0c491e2034caa90123cdf8c9e7c00 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-04-10T00:30:27Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-fdc0c491e2034caa90123cdf8c9e7c002023-03-15T04:28:06ZengElsevierRespiratory Medicine Case Reports2213-00712023-01-0142101816A rare case of vasculitis in cystic fibrosis: A clinical caseSabrina Nasreddine0Mitchelle Issa1Zeina Aoun Bacha2Corresponding author.; Department of Pulmonology-Critical Care, Hotel Dieu de France UHC, St Joseph University, Beirut, LebanonDepartment of Pulmonology-Critical Care, Hotel Dieu de France UHC, St Joseph University, Beirut, LebanonDepartment of Pulmonology-Critical Care, Hotel Dieu de France UHC, St Joseph University, Beirut, LebanonIntroduction: Cystic fibrosis is known to cause serious complications, such as recurrent pulmonary infections, pancreatic insufficiency, and other symptoms related to exocrine gland dysfunction. A rare manifestation of the disease is discussed in this case of a 24-year-old female diagnosed with cystic fibrosis, a purpuric rash was documented during pulmonary infection flares. Skin biopsy shows a leukocytoclastic vasculitis eruption along with infection. Treatment options are limited and not well established. Our patient received a treatment based on colchicine 1mg per day with a total response. The patient was observed during two consecutive pulmonary infection flares separated by a few months, and a total remission without recurrence was found. Conclusion: Considering its efficacy and safety, further scientific research about colchicine and vasculitis in cystic fibrosis should be aimed at in order to define a strong consensus between the disease and this treatment option.http://www.sciencedirect.com/science/article/pii/S2213007123000114Purpuric rashCystic fibrosisBronchiectasisLeukocytoclastic vasculitisColchicine |
| spellingShingle | Sabrina Nasreddine Mitchelle Issa Zeina Aoun Bacha A rare case of vasculitis in cystic fibrosis: A clinical case Respiratory Medicine Case Reports Purpuric rash Cystic fibrosis Bronchiectasis Leukocytoclastic vasculitis Colchicine |
| title | A rare case of vasculitis in cystic fibrosis: A clinical case |
| title_full | A rare case of vasculitis in cystic fibrosis: A clinical case |
| title_fullStr | A rare case of vasculitis in cystic fibrosis: A clinical case |
| title_full_unstemmed | A rare case of vasculitis in cystic fibrosis: A clinical case |
| title_short | A rare case of vasculitis in cystic fibrosis: A clinical case |
| title_sort | rare case of vasculitis in cystic fibrosis a clinical case |
| topic | Purpuric rash Cystic fibrosis Bronchiectasis Leukocytoclastic vasculitis Colchicine |
| url | http://www.sciencedirect.com/science/article/pii/S2213007123000114 |
| work_keys_str_mv | AT sabrinanasreddine ararecaseofvasculitisincysticfibrosisaclinicalcase AT mitchelleissa ararecaseofvasculitisincysticfibrosisaclinicalcase AT zeinaaounbacha ararecaseofvasculitisincysticfibrosisaclinicalcase AT sabrinanasreddine rarecaseofvasculitisincysticfibrosisaclinicalcase AT mitchelleissa rarecaseofvasculitisincysticfibrosisaclinicalcase AT zeinaaounbacha rarecaseofvasculitisincysticfibrosisaclinicalcase |