Soluble Urokinase Plasminogen Activator Receptor (suPAR) in Autoimmune Rheumatic and Non Rheumatic Diseases
The soluble urokinase plasminogen activator receptor (suPAR) is the bioactive form of uPAR, a membrane-bound glycoprotein, and it is primarily expressed on the surface of immunologically active cells. Mirroring local inflammation and immune activation, suPAR has gained interest as a potential progno...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/4/688 |
| _version_ | 1797604778259251200 |
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| author | Mariangela Manfredi Lieve Van Hoovels Maurizio Benucci Riccardo De Luca Carmela Coccia Pamela Bernardini Edda Russo Amedeo Amedei Serena Guiducci Valentina Grossi Xavier Bossuyt Carlo Perricone Maria Infantino |
| author_facet | Mariangela Manfredi Lieve Van Hoovels Maurizio Benucci Riccardo De Luca Carmela Coccia Pamela Bernardini Edda Russo Amedeo Amedei Serena Guiducci Valentina Grossi Xavier Bossuyt Carlo Perricone Maria Infantino |
| author_sort | Mariangela Manfredi |
| collection | DOAJ |
| description | The soluble urokinase plasminogen activator receptor (suPAR) is the bioactive form of uPAR, a membrane-bound glycoprotein, and it is primarily expressed on the surface of immunologically active cells. Mirroring local inflammation and immune activation, suPAR has gained interest as a potential prognostic biomarker in several inflammatory diseases. Indeed, in many diseases, including cancer, diabetes, cardiovascular diseases, kidney diseases, and inflammatory disorders, higher suPAR concentrations have been associated with disease severity, disease relapse, and mortality. Our review describes and discusses the supporting literature concerning the promising role of suPAR as a biomarker in different autoimmune rheumatic and non-rheumatic diseases. |
| first_indexed | 2024-03-11T04:51:35Z |
| format | Article |
| id | doaj.art-fdc0d76db11845698be2a848e468f2ba |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T04:51:35Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-fdc0d76db11845698be2a848e468f2ba2023-11-17T20:00:45ZengMDPI AGJournal of Personalized Medicine2075-44262023-04-0113468810.3390/jpm13040688Soluble Urokinase Plasminogen Activator Receptor (suPAR) in Autoimmune Rheumatic and Non Rheumatic DiseasesMariangela Manfredi0Lieve Van Hoovels1Maurizio Benucci2Riccardo De Luca3Carmela Coccia4Pamela Bernardini5Edda Russo6Amedeo Amedei7Serena Guiducci8Valentina Grossi9Xavier Bossuyt10Carlo Perricone11Maria Infantino12Immunology and Allergology Laboratory Unit, S. Giovanni di Dio Hospital, 50143 Florence, ItalyDepartment of Microbiology, Immunology and Transplantation, University of Leuven, 3000 Leuven, BelgiumRheumatology Unit, S. Giovanni di Dio Hospital, 50143 Florence, ItalyDepartment of Clinical and Experimental Medicine, University of Florence, 50139 Florence, ItalyDepartment of Clinical and Experimental Medicine, University of Florence, 50139 Florence, ItalyDepartment of Clinical and Experimental Medicine, University of Florence, 50139 Florence, ItalyDepartment of Clinical and Experimental Medicine, University of Florence, 50139 Florence, ItalyDepartment of Clinical and Experimental Medicine, University of Florence, 50139 Florence, ItalyDepartment of Clinical and Experimental Medicine, University of Florence, 50139 Florence, ItalyImmunology and Allergology Laboratory Unit, S. Giovanni di Dio Hospital, 50143 Florence, ItalyDepartment of Microbiology, Immunology and Transplantation, University of Leuven, 3000 Leuven, BelgiumRheumatology Unit, Department of Medicine and Surgery, University of Perugia, 06122 Perugia, ItalyImmunology and Allergology Laboratory Unit, S. Giovanni di Dio Hospital, 50143 Florence, ItalyThe soluble urokinase plasminogen activator receptor (suPAR) is the bioactive form of uPAR, a membrane-bound glycoprotein, and it is primarily expressed on the surface of immunologically active cells. Mirroring local inflammation and immune activation, suPAR has gained interest as a potential prognostic biomarker in several inflammatory diseases. Indeed, in many diseases, including cancer, diabetes, cardiovascular diseases, kidney diseases, and inflammatory disorders, higher suPAR concentrations have been associated with disease severity, disease relapse, and mortality. Our review describes and discusses the supporting literature concerning the promising role of suPAR as a biomarker in different autoimmune rheumatic and non-rheumatic diseases.https://www.mdpi.com/2075-4426/13/4/688suPARrheumatoid arthritisautoimmune diseasesrheumatic diseases |
| spellingShingle | Mariangela Manfredi Lieve Van Hoovels Maurizio Benucci Riccardo De Luca Carmela Coccia Pamela Bernardini Edda Russo Amedeo Amedei Serena Guiducci Valentina Grossi Xavier Bossuyt Carlo Perricone Maria Infantino Soluble Urokinase Plasminogen Activator Receptor (suPAR) in Autoimmune Rheumatic and Non Rheumatic Diseases Journal of Personalized Medicine suPAR rheumatoid arthritis autoimmune diseases rheumatic diseases |
| title | Soluble Urokinase Plasminogen Activator Receptor (suPAR) in Autoimmune Rheumatic and Non Rheumatic Diseases |
| title_full | Soluble Urokinase Plasminogen Activator Receptor (suPAR) in Autoimmune Rheumatic and Non Rheumatic Diseases |
| title_fullStr | Soluble Urokinase Plasminogen Activator Receptor (suPAR) in Autoimmune Rheumatic and Non Rheumatic Diseases |
| title_full_unstemmed | Soluble Urokinase Plasminogen Activator Receptor (suPAR) in Autoimmune Rheumatic and Non Rheumatic Diseases |
| title_short | Soluble Urokinase Plasminogen Activator Receptor (suPAR) in Autoimmune Rheumatic and Non Rheumatic Diseases |
| title_sort | soluble urokinase plasminogen activator receptor supar in autoimmune rheumatic and non rheumatic diseases |
| topic | suPAR rheumatoid arthritis autoimmune diseases rheumatic diseases |
| url | https://www.mdpi.com/2075-4426/13/4/688 |
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