Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations

Abstract We aimed to assess the association between heated tobacco product (HTP) use and high-density lipoprotein cholesterol (HDL-C) concentration. Our study included 12,268 workers from five companies (Study I) and 36,503 workers from another large company (Study II). Participants were categorized...

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Main Authors: Huan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Toshiaki Miyamoto, Hiroko Okazaki, Masafumi Eguchi, Taiki Shirasaka, Takeshi Kochi, Isamu Kabe, Aki Tomizawa, Takako Miki, Ami Fukunaga, Shohei Yamamoto, Yosuke Inoue, Maki Konishi, Haruka Miyake, Seitaro Dohi, Tetsuya Mizoue
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-22337-3
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author Huan Hu
Tohru Nakagawa
Toru Honda
Shuichiro Yamamoto
Toshiaki Miyamoto
Hiroko Okazaki
Masafumi Eguchi
Taiki Shirasaka
Takeshi Kochi
Isamu Kabe
Aki Tomizawa
Takako Miki
Ami Fukunaga
Shohei Yamamoto
Yosuke Inoue
Maki Konishi
Haruka Miyake
Seitaro Dohi
Tetsuya Mizoue
author_facet Huan Hu
Tohru Nakagawa
Toru Honda
Shuichiro Yamamoto
Toshiaki Miyamoto
Hiroko Okazaki
Masafumi Eguchi
Taiki Shirasaka
Takeshi Kochi
Isamu Kabe
Aki Tomizawa
Takako Miki
Ami Fukunaga
Shohei Yamamoto
Yosuke Inoue
Maki Konishi
Haruka Miyake
Seitaro Dohi
Tetsuya Mizoue
author_sort Huan Hu
collection DOAJ
description Abstract We aimed to assess the association between heated tobacco product (HTP) use and high-density lipoprotein cholesterol (HDL-C) concentration. Our study included 12,268 workers from five companies (Study I) and 36,503 workers from another large company (Study II). Participants were categorized into five groups: never smokers, past smokers, exclusive HTP users, dual users of cigarettes and HTPs, and exclusive cigarette smokers. We analyzed the data of Studies I and II separately and then pooled these estimates using a fixed-effect model. Of the 48,771 participants, 9.3% were exclusive HTP users, and 6.0% were dual users. Exclusive HTP users had modestly but significantly lower concentrations of HDL-C than never smokers, with the pooled mean difference being − 1.1 (95% CI − 1.5 to − 0.6) mg/dL. Dual users showed a further reduction (mean difference − 3.7 (− 4.2 to − 3.2) mg/dL), which was comparable to that of exclusive cigarette smokers versus never smokers (mean difference − 4.3 (− 4.7 to − 3.9) mg/dL). The pooled odds ratios (95% CIs) of having low HDL-C (< 40 mg/dL for men and 50 mg/dL for women) were 1, 0.99 (0.90–1.11), 1.25 (1.09–1.43), 2.02 (1.76–2.32), and 2.09 (1.88–2.32) for never smokers, past smokers, exclusive HTP users, dual users, and exclusive cigarette smokers, respectively. In conclusion, exclusive HTP users had lower HDL-C concentrations than never smokers, although higher than exclusive cigarette smokers. Moreover, dual users had HDL-C concentrations similar to those in exclusive cigarette smokers.
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spelling doaj.art-fdc267510f3e4feaa9db07113d6e38ed2022-12-22T04:37:01ZengNature PortfolioScientific Reports2045-23222022-10-011211610.1038/s41598-022-22337-3Heated tobacco products and circulating high-density lipoprotein cholesterol concentrationsHuan Hu0Tohru Nakagawa1Toru Honda2Shuichiro Yamamoto3Toshiaki Miyamoto4Hiroko Okazaki5Masafumi Eguchi6Taiki Shirasaka7Takeshi Kochi8Isamu Kabe9Aki Tomizawa10Takako Miki11Ami Fukunaga12Shohei Yamamoto13Yosuke Inoue14Maki Konishi15Haruka Miyake16Seitaro Dohi17Tetsuya Mizoue18Research Center for Prevention From Radiation Hazards of Workers, National Institute of Occupational Safety and HealthHitachi Health Care Center, Hitachi, Ltd.Hitachi Health Care Center, Hitachi, Ltd.Hitachi Health Care Center, Hitachi, Ltd.Nippon Steel Corporation, East Nippon Works Kimitsu AreaMitsui Chemicals, Inc.Furukawa Electric Co., Ltd.Furukawa Electric Co., Ltd.Furukawa Electric Co., Ltd.KUBOTA Corporation Co., Ltd.Health Design Inc.Department of Epidemiology and Prevention, National Center for Global Health and MedicineDepartment of Epidemiology and Prevention, National Center for Global Health and MedicineDepartment of Epidemiology and Prevention, National Center for Global Health and MedicineDepartment of Epidemiology and Prevention, National Center for Global Health and MedicineDepartment of Epidemiology and Prevention, National Center for Global Health and MedicineDepartment of Epidemiology and Prevention, National Center for Global Health and MedicineMitsui Chemicals, Inc.Department of Epidemiology and Prevention, National Center for Global Health and MedicineAbstract We aimed to assess the association between heated tobacco product (HTP) use and high-density lipoprotein cholesterol (HDL-C) concentration. Our study included 12,268 workers from five companies (Study I) and 36,503 workers from another large company (Study II). Participants were categorized into five groups: never smokers, past smokers, exclusive HTP users, dual users of cigarettes and HTPs, and exclusive cigarette smokers. We analyzed the data of Studies I and II separately and then pooled these estimates using a fixed-effect model. Of the 48,771 participants, 9.3% were exclusive HTP users, and 6.0% were dual users. Exclusive HTP users had modestly but significantly lower concentrations of HDL-C than never smokers, with the pooled mean difference being − 1.1 (95% CI − 1.5 to − 0.6) mg/dL. Dual users showed a further reduction (mean difference − 3.7 (− 4.2 to − 3.2) mg/dL), which was comparable to that of exclusive cigarette smokers versus never smokers (mean difference − 4.3 (− 4.7 to − 3.9) mg/dL). The pooled odds ratios (95% CIs) of having low HDL-C (< 40 mg/dL for men and 50 mg/dL for women) were 1, 0.99 (0.90–1.11), 1.25 (1.09–1.43), 2.02 (1.76–2.32), and 2.09 (1.88–2.32) for never smokers, past smokers, exclusive HTP users, dual users, and exclusive cigarette smokers, respectively. In conclusion, exclusive HTP users had lower HDL-C concentrations than never smokers, although higher than exclusive cigarette smokers. Moreover, dual users had HDL-C concentrations similar to those in exclusive cigarette smokers.https://doi.org/10.1038/s41598-022-22337-3
spellingShingle Huan Hu
Tohru Nakagawa
Toru Honda
Shuichiro Yamamoto
Toshiaki Miyamoto
Hiroko Okazaki
Masafumi Eguchi
Taiki Shirasaka
Takeshi Kochi
Isamu Kabe
Aki Tomizawa
Takako Miki
Ami Fukunaga
Shohei Yamamoto
Yosuke Inoue
Maki Konishi
Haruka Miyake
Seitaro Dohi
Tetsuya Mizoue
Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations
Scientific Reports
title Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations
title_full Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations
title_fullStr Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations
title_full_unstemmed Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations
title_short Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations
title_sort heated tobacco products and circulating high density lipoprotein cholesterol concentrations
url https://doi.org/10.1038/s41598-022-22337-3
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