Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations
Abstract We aimed to assess the association between heated tobacco product (HTP) use and high-density lipoprotein cholesterol (HDL-C) concentration. Our study included 12,268 workers from five companies (Study I) and 36,503 workers from another large company (Study II). Participants were categorized...
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Nature Portfolio
2022-10-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-22337-3 |
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author | Huan Hu Tohru Nakagawa Toru Honda Shuichiro Yamamoto Toshiaki Miyamoto Hiroko Okazaki Masafumi Eguchi Taiki Shirasaka Takeshi Kochi Isamu Kabe Aki Tomizawa Takako Miki Ami Fukunaga Shohei Yamamoto Yosuke Inoue Maki Konishi Haruka Miyake Seitaro Dohi Tetsuya Mizoue |
author_facet | Huan Hu Tohru Nakagawa Toru Honda Shuichiro Yamamoto Toshiaki Miyamoto Hiroko Okazaki Masafumi Eguchi Taiki Shirasaka Takeshi Kochi Isamu Kabe Aki Tomizawa Takako Miki Ami Fukunaga Shohei Yamamoto Yosuke Inoue Maki Konishi Haruka Miyake Seitaro Dohi Tetsuya Mizoue |
author_sort | Huan Hu |
collection | DOAJ |
description | Abstract We aimed to assess the association between heated tobacco product (HTP) use and high-density lipoprotein cholesterol (HDL-C) concentration. Our study included 12,268 workers from five companies (Study I) and 36,503 workers from another large company (Study II). Participants were categorized into five groups: never smokers, past smokers, exclusive HTP users, dual users of cigarettes and HTPs, and exclusive cigarette smokers. We analyzed the data of Studies I and II separately and then pooled these estimates using a fixed-effect model. Of the 48,771 participants, 9.3% were exclusive HTP users, and 6.0% were dual users. Exclusive HTP users had modestly but significantly lower concentrations of HDL-C than never smokers, with the pooled mean difference being − 1.1 (95% CI − 1.5 to − 0.6) mg/dL. Dual users showed a further reduction (mean difference − 3.7 (− 4.2 to − 3.2) mg/dL), which was comparable to that of exclusive cigarette smokers versus never smokers (mean difference − 4.3 (− 4.7 to − 3.9) mg/dL). The pooled odds ratios (95% CIs) of having low HDL-C (< 40 mg/dL for men and 50 mg/dL for women) were 1, 0.99 (0.90–1.11), 1.25 (1.09–1.43), 2.02 (1.76–2.32), and 2.09 (1.88–2.32) for never smokers, past smokers, exclusive HTP users, dual users, and exclusive cigarette smokers, respectively. In conclusion, exclusive HTP users had lower HDL-C concentrations than never smokers, although higher than exclusive cigarette smokers. Moreover, dual users had HDL-C concentrations similar to those in exclusive cigarette smokers. |
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institution | Directory Open Access Journal |
issn | 2045-2322 |
language | English |
last_indexed | 2024-04-11T07:28:12Z |
publishDate | 2022-10-01 |
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spelling | doaj.art-fdc267510f3e4feaa9db07113d6e38ed2022-12-22T04:37:01ZengNature PortfolioScientific Reports2045-23222022-10-011211610.1038/s41598-022-22337-3Heated tobacco products and circulating high-density lipoprotein cholesterol concentrationsHuan Hu0Tohru Nakagawa1Toru Honda2Shuichiro Yamamoto3Toshiaki Miyamoto4Hiroko Okazaki5Masafumi Eguchi6Taiki Shirasaka7Takeshi Kochi8Isamu Kabe9Aki Tomizawa10Takako Miki11Ami Fukunaga12Shohei Yamamoto13Yosuke Inoue14Maki Konishi15Haruka Miyake16Seitaro Dohi17Tetsuya Mizoue18Research Center for Prevention From Radiation Hazards of Workers, National Institute of Occupational Safety and HealthHitachi Health Care Center, Hitachi, Ltd.Hitachi Health Care Center, Hitachi, Ltd.Hitachi Health Care Center, Hitachi, Ltd.Nippon Steel Corporation, East Nippon Works Kimitsu AreaMitsui Chemicals, Inc.Furukawa Electric Co., Ltd.Furukawa Electric Co., Ltd.Furukawa Electric Co., Ltd.KUBOTA Corporation Co., Ltd.Health Design Inc.Department of Epidemiology and Prevention, National Center for Global Health and MedicineDepartment of Epidemiology and Prevention, National Center for Global Health and MedicineDepartment of Epidemiology and Prevention, National Center for Global Health and MedicineDepartment of Epidemiology and Prevention, National Center for Global Health and MedicineDepartment of Epidemiology and Prevention, National Center for Global Health and MedicineDepartment of Epidemiology and Prevention, National Center for Global Health and MedicineMitsui Chemicals, Inc.Department of Epidemiology and Prevention, National Center for Global Health and MedicineAbstract We aimed to assess the association between heated tobacco product (HTP) use and high-density lipoprotein cholesterol (HDL-C) concentration. Our study included 12,268 workers from five companies (Study I) and 36,503 workers from another large company (Study II). Participants were categorized into five groups: never smokers, past smokers, exclusive HTP users, dual users of cigarettes and HTPs, and exclusive cigarette smokers. We analyzed the data of Studies I and II separately and then pooled these estimates using a fixed-effect model. Of the 48,771 participants, 9.3% were exclusive HTP users, and 6.0% were dual users. Exclusive HTP users had modestly but significantly lower concentrations of HDL-C than never smokers, with the pooled mean difference being − 1.1 (95% CI − 1.5 to − 0.6) mg/dL. Dual users showed a further reduction (mean difference − 3.7 (− 4.2 to − 3.2) mg/dL), which was comparable to that of exclusive cigarette smokers versus never smokers (mean difference − 4.3 (− 4.7 to − 3.9) mg/dL). The pooled odds ratios (95% CIs) of having low HDL-C (< 40 mg/dL for men and 50 mg/dL for women) were 1, 0.99 (0.90–1.11), 1.25 (1.09–1.43), 2.02 (1.76–2.32), and 2.09 (1.88–2.32) for never smokers, past smokers, exclusive HTP users, dual users, and exclusive cigarette smokers, respectively. In conclusion, exclusive HTP users had lower HDL-C concentrations than never smokers, although higher than exclusive cigarette smokers. Moreover, dual users had HDL-C concentrations similar to those in exclusive cigarette smokers.https://doi.org/10.1038/s41598-022-22337-3 |
spellingShingle | Huan Hu Tohru Nakagawa Toru Honda Shuichiro Yamamoto Toshiaki Miyamoto Hiroko Okazaki Masafumi Eguchi Taiki Shirasaka Takeshi Kochi Isamu Kabe Aki Tomizawa Takako Miki Ami Fukunaga Shohei Yamamoto Yosuke Inoue Maki Konishi Haruka Miyake Seitaro Dohi Tetsuya Mizoue Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations Scientific Reports |
title | Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations |
title_full | Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations |
title_fullStr | Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations |
title_full_unstemmed | Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations |
title_short | Heated tobacco products and circulating high-density lipoprotein cholesterol concentrations |
title_sort | heated tobacco products and circulating high density lipoprotein cholesterol concentrations |
url | https://doi.org/10.1038/s41598-022-22337-3 |
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