Molecular markers in the diagnosis and prognosis of sepsis, severe sepsis and septic shock
Introduction: Despite important progress in the understanding of the pathophysiology of sepsis, the mortality rates caused by this condition remain high. Objective: To describe the state of the art on molecular biomarkers proposed as potential markers for the diagnosis and prognosis of sepsis, sever...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2017-01-01
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| Series: | Revista de la Facultad de Medicina |
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| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/53876 |
| _version_ | 1819011360819773440 |
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| author | Alfredo Prado-Díaz Andrés Castillo Diana Marcela Rojas Mónica Chávez-Vivas |
| author_facet | Alfredo Prado-Díaz Andrés Castillo Diana Marcela Rojas Mónica Chávez-Vivas |
| author_sort | Alfredo Prado-Díaz |
| collection | DOAJ |
| description | Introduction: Despite important progress in the understanding of the pathophysiology of sepsis, the mortality rates caused by this condition remain high.
Objective: To describe the state of the art on molecular biomarkers proposed as potential markers for the diagnosis and prognosis of sepsis, severe sepsis and septic shock.
Materials and methods: The terms sepsis, genetic polymorphisms, genetic variation and molecular marker were analyzed in the records of the last 14 years of PubMed, the New England Journal of Medicine (NEJM) and Illinois Automatic Computer (ILLIAC). The papers were classified by year of publication; only those published within the last 10 years were taken into account.
Results: The search yielded 3390 references covering more than 30 genes with genetic polymorphisms that can be used as potential polymorphism markers. They were assessed for use in different manifestations, diagnosis and progression of sepsis. Twenty genetic markers are described: four associated with bacteremia (TLR-1, TLR-2, Protein C and Selectin-E), nine with sepsis (IL-1B, IL-1A, IL-6, TNF-α, TLR-1, MBL-1, Hsp70, PAI-1 and MIF-1), seven with severe sepsis (IL-1RN, IL-10, TNF-α, CD14, TREM-1, Caspase 12 and DEFB-1), five with septic shock (TNF-B, TLR-4, Hsp70, MBL-1 and CD14 ), and three with multiorgan dysfunction (TLR-1, PAI-1 and Protein C).
Conclusion: In general, genetic polymorphisms have been clinically tested as diagnostic and prognostic markers of sepsis with promising results due to the high specificity and sensitivity of the clinical practice. |
| first_indexed | 2024-12-21T01:26:56Z |
| format | Article |
| id | doaj.art-fdc44daa922345c39715a3054d1ae40f |
| institution | Directory Open Access Journal |
| issn | 0120-0011 2357-3848 |
| language | English |
| last_indexed | 2024-12-21T01:26:56Z |
| publishDate | 2017-01-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Revista de la Facultad de Medicina |
| spelling | doaj.art-fdc44daa922345c39715a3054d1ae40f2022-12-21T19:20:29ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482017-01-0165114515510.15446/revfacmed.v65n1.5387645767Molecular markers in the diagnosis and prognosis of sepsis, severe sepsis and septic shockAlfredo Prado-Díaz0Andrés Castillo1Diana Marcela Rojas2Mónica Chávez-Vivas3Universidad Libre - Seccional Cali - Grupo de Investigación en Microbiología Molecular y Enfermedades Infecciosas (GIMMEIN) - Santiago de Cali- Colombia.Universidad del Valle - Sede Cali - Facultad de Ciencias Naturales y Exactas - Departamento de Biología - Cali - Colombia.Universidad Andres Bello - Sede Santiago - Facultad de Medicina - Escuela de Nutrición y Dietética - Santiago de Chile - Chile.Universidad Santiago de Cali - Campus Pampalinda - Facultad de Salud - Departamento de Ciencias Biomédicas - Santiago de Cali - Colombia. Universidad Libre de Cali - Seccional Cali - Grupo de Investigación Instituto de Ciencias Biomédicas - Cali - Colombia.Introduction: Despite important progress in the understanding of the pathophysiology of sepsis, the mortality rates caused by this condition remain high. Objective: To describe the state of the art on molecular biomarkers proposed as potential markers for the diagnosis and prognosis of sepsis, severe sepsis and septic shock. Materials and methods: The terms sepsis, genetic polymorphisms, genetic variation and molecular marker were analyzed in the records of the last 14 years of PubMed, the New England Journal of Medicine (NEJM) and Illinois Automatic Computer (ILLIAC). The papers were classified by year of publication; only those published within the last 10 years were taken into account. Results: The search yielded 3390 references covering more than 30 genes with genetic polymorphisms that can be used as potential polymorphism markers. They were assessed for use in different manifestations, diagnosis and progression of sepsis. Twenty genetic markers are described: four associated with bacteremia (TLR-1, TLR-2, Protein C and Selectin-E), nine with sepsis (IL-1B, IL-1A, IL-6, TNF-α, TLR-1, MBL-1, Hsp70, PAI-1 and MIF-1), seven with severe sepsis (IL-1RN, IL-10, TNF-α, CD14, TREM-1, Caspase 12 and DEFB-1), five with septic shock (TNF-B, TLR-4, Hsp70, MBL-1 and CD14 ), and three with multiorgan dysfunction (TLR-1, PAI-1 and Protein C). Conclusion: In general, genetic polymorphisms have been clinically tested as diagnostic and prognostic markers of sepsis with promising results due to the high specificity and sensitivity of the clinical practice.https://revistas.unal.edu.co/index.php/revfacmed/article/view/53876SepsisBiomarcadoresPolimorfismo genéticoPolimorfismo de nucleótido simpleRepeticiones de minisatélite |
| spellingShingle | Alfredo Prado-Díaz Andrés Castillo Diana Marcela Rojas Mónica Chávez-Vivas Molecular markers in the diagnosis and prognosis of sepsis, severe sepsis and septic shock Revista de la Facultad de Medicina Sepsis Biomarcadores Polimorfismo genético Polimorfismo de nucleótido simple Repeticiones de minisatélite |
| title | Molecular markers in the diagnosis and prognosis of sepsis, severe sepsis and septic shock |
| title_full | Molecular markers in the diagnosis and prognosis of sepsis, severe sepsis and septic shock |
| title_fullStr | Molecular markers in the diagnosis and prognosis of sepsis, severe sepsis and septic shock |
| title_full_unstemmed | Molecular markers in the diagnosis and prognosis of sepsis, severe sepsis and septic shock |
| title_short | Molecular markers in the diagnosis and prognosis of sepsis, severe sepsis and septic shock |
| title_sort | molecular markers in the diagnosis and prognosis of sepsis severe sepsis and septic shock |
| topic | Sepsis Biomarcadores Polimorfismo genético Polimorfismo de nucleótido simple Repeticiones de minisatélite |
| url | https://revistas.unal.edu.co/index.php/revfacmed/article/view/53876 |
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