Model-based exploration of the rationality of off-label use of cetirizine in Chinese pediatric patients: a prospective cohort study

Model-based exploration of the rationality of off-label use of cetirizine in Chinese pediatric patients: a prospective cohort study

Aims: Cetirizine is frequently administered at an increased dosage in clinical practice and recommended by several guidelines. Nonetheless, the pharmacokinetic (PK) profile and real-world safety data remain insufficient in the Chinese pediatric population. The objective of the current study is to de...

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Bibliographic Details
Main Authors: Wei Liu, Zhiyuan Tan, Ping Yang, Zhiheng Yu, Xueting Yao, Pengxiang Zhou, Ling Liu, Wei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
cetirizine
allergic diseases
antihistamines
population pharmacokinetics
off-label use
modeling and simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1322788/full

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