Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis
To achieve sufficient blood–brain barrier (BBB), penetration is one of the biggest challenges in the development of diagnostic and therapeutic for central nervous system (CNS) disorders. Here, we conducted a systematic review and meta-analysis to assess the preclinical evidence and possible mechanis...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-01-01
|
| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2018.1486471 |
| _version_ | 1819230682799407104 |
|---|---|
| author | Qun Zheng Zi-Xian Chen Meng-Bei Xu Xiao-Li Zhou Yue-Yue Huang Guo-Qing Zheng Yan Wang |
| author_facet | Qun Zheng Zi-Xian Chen Meng-Bei Xu Xiao-Li Zhou Yue-Yue Huang Guo-Qing Zheng Yan Wang |
| author_sort | Qun Zheng |
| collection | DOAJ |
| description | To achieve sufficient blood–brain barrier (BBB), penetration is one of the biggest challenges in the development of diagnostic and therapeutic for central nervous system (CNS) disorders. Here, we conducted a systematic review and meta-analysis to assess the preclinical evidence and possible mechanisms of borneol for improving co-administration of CNS drug delivery in animal models. The electronic literature search was conducted in six databases. Fifty-eight studies with 63 comparisons involved 1137 animals were included. Among 47 studies reporting the assessments of CNS drug concentration, 45 studies showed the significant effects of borneol for improving CNS drug delivery (p<.05), whereas 2 studies showed no difference (p>.05). Nineteen comparisons showed borneol up-regulated BBB permeability (p<.05) using brain EB content (n = 8), Rh 123 content (n = 4), brain imaging agent content (n = 2), brain water content (n = 1) and observing ultrastructure of BBB (n = 4), whereas three studies showed no difference or unclear results. Seven studies reported the safety, in which one study showed borneol was reversible changes in the BBB penetration; six studies showed borneol did not increase co-administration of blood drugs concentration of peripheral tissues (p > .05). Effects of borneol are closely associated with inhibition of efflux protein function, releasement of tight junction protein, increasement of vasodilatory neurotransmitters, and inhibition of active transport by ion channels. In conclusion, borneol is a promising candidate for CNS drug delivery, mainly through mediating a multi-targeted BBB permeability. |
| first_indexed | 2024-12-23T11:32:57Z |
| format | Article |
| id | doaj.art-fdc54f6ea4fb4c3591857c01d1a38bb3 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-23T11:32:57Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-fdc54f6ea4fb4c3591857c01d1a38bb32022-12-21T17:48:45ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642018-01-012511617163310.1080/10717544.2018.14864711486471Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysisQun Zheng0Zi-Xian Chen1Meng-Bei Xu2Xiao-Li Zhou3Yue-Yue Huang4Guo-Qing Zheng5Yan Wang6The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityThe Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityTo achieve sufficient blood–brain barrier (BBB), penetration is one of the biggest challenges in the development of diagnostic and therapeutic for central nervous system (CNS) disorders. Here, we conducted a systematic review and meta-analysis to assess the preclinical evidence and possible mechanisms of borneol for improving co-administration of CNS drug delivery in animal models. The electronic literature search was conducted in six databases. Fifty-eight studies with 63 comparisons involved 1137 animals were included. Among 47 studies reporting the assessments of CNS drug concentration, 45 studies showed the significant effects of borneol for improving CNS drug delivery (p<.05), whereas 2 studies showed no difference (p>.05). Nineteen comparisons showed borneol up-regulated BBB permeability (p<.05) using brain EB content (n = 8), Rh 123 content (n = 4), brain imaging agent content (n = 2), brain water content (n = 1) and observing ultrastructure of BBB (n = 4), whereas three studies showed no difference or unclear results. Seven studies reported the safety, in which one study showed borneol was reversible changes in the BBB penetration; six studies showed borneol did not increase co-administration of blood drugs concentration of peripheral tissues (p > .05). Effects of borneol are closely associated with inhibition of efflux protein function, releasement of tight junction protein, increasement of vasodilatory neurotransmitters, and inhibition of active transport by ion channels. In conclusion, borneol is a promising candidate for CNS drug delivery, mainly through mediating a multi-targeted BBB permeability.http://dx.doi.org/10.1080/10717544.2018.1486471borneolblood–brain barrierdrug deliverypreclinical evidencepossible mechanisms |
| spellingShingle | Qun Zheng Zi-Xian Chen Meng-Bei Xu Xiao-Li Zhou Yue-Yue Huang Guo-Qing Zheng Yan Wang Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis Drug Delivery borneol blood–brain barrier drug delivery preclinical evidence possible mechanisms |
| title | Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis |
| title_full | Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis |
| title_fullStr | Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis |
| title_full_unstemmed | Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis |
| title_short | Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis |
| title_sort | borneol a messenger agent improves central nervous system drug delivery through enhancing blood brain barrier permeability a preclinical systematic review and meta analysis |
| topic | borneol blood–brain barrier drug delivery preclinical evidence possible mechanisms |
| url | http://dx.doi.org/10.1080/10717544.2018.1486471 |
| work_keys_str_mv | AT qunzheng borneolamessengeragentimprovescentralnervoussystemdrugdeliverythroughenhancingbloodbrainbarrierpermeabilityapreclinicalsystematicreviewandmetaanalysis AT zixianchen borneolamessengeragentimprovescentralnervoussystemdrugdeliverythroughenhancingbloodbrainbarrierpermeabilityapreclinicalsystematicreviewandmetaanalysis AT mengbeixu borneolamessengeragentimprovescentralnervoussystemdrugdeliverythroughenhancingbloodbrainbarrierpermeabilityapreclinicalsystematicreviewandmetaanalysis AT xiaolizhou borneolamessengeragentimprovescentralnervoussystemdrugdeliverythroughenhancingbloodbrainbarrierpermeabilityapreclinicalsystematicreviewandmetaanalysis AT yueyuehuang borneolamessengeragentimprovescentralnervoussystemdrugdeliverythroughenhancingbloodbrainbarrierpermeabilityapreclinicalsystematicreviewandmetaanalysis AT guoqingzheng borneolamessengeragentimprovescentralnervoussystemdrugdeliverythroughenhancingbloodbrainbarrierpermeabilityapreclinicalsystematicreviewandmetaanalysis AT yanwang borneolamessengeragentimprovescentralnervoussystemdrugdeliverythroughenhancingbloodbrainbarrierpermeabilityapreclinicalsystematicreviewandmetaanalysis |