Proteomic analysis of magnesium-dependent proteins and children’s health
Systems biology analysis of over 700 magnesium-dependent proteins in human proteome shown that these proteins affect (1) the embryonic development, (2) energy metabolism, (3) signal transduction processes from receptors, (4) neurological function, (5) support of connective tissue structure, (6) card...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2017-12-01
|
| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/1680 |
| _version_ | 1797842209271185408 |
|---|---|
| author | O. A. Gromova I. Yu. Torshin N. I. Tapilskaya |
| author_facet | O. A. Gromova I. Yu. Torshin N. I. Tapilskaya |
| author_sort | O. A. Gromova |
| collection | DOAJ |
| description | Systems biology analysis of over 700 magnesium-dependent proteins in human proteome shown that these proteins affect (1) the embryonic development, (2) energy metabolism, (3) signal transduction processes from receptors, (4) neurological function, (5) support of connective tissue structure, (6) cardiovascular and (7) immunological roles. Magnesium deficiency during pregnancy will stimulate development of congential malformations (skeletal defects, rickets, hernia of the diaphragm, facial defects, craniosynostosis, structural disorders of the retina and vision, brachydactyly). Magnesium deficiency at an early age is associated with sudden death syndrome in preschool and adolescence leads to impaired function of skeletal muscles and myocardium. Magnesium deficiency is also characterized by mitochondrial disorders, hyperinsulinemia, disorders of the skin structure and its appendages, tumors and diseases associated with impaired energy metabolism (including hypoparathyroidism and anemia). Effects of magnesium deficiency in children significantly heavier on the background of lack of vitamin B6 (pyridoxine). The results of proteomic analysis enable to point out the relevant molecular and physiological mechanisms of synergy between magnesium and pyridoxine. Overall, the results of the analysis indicate a very extensive area for the correction of magnesium and pyridoxine deficiency for the prevention and treatment of a wide range of diseases, from the period of fetal development and early childhood through adolescence. |
| first_indexed | 2024-04-09T16:44:06Z |
| format | Article |
| id | doaj.art-fdc7fb38d79642a59700c0e084d2134e |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:44:06Z |
| publishDate | 2017-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-fdc7fb38d79642a59700c0e084d2134e2023-04-23T06:56:35ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902017-12-0101667610.21518/2079-701X-2017-1-66-761667Proteomic analysis of magnesium-dependent proteins and children’s healthO. A. Gromova0I. Yu. Torshin1N. I. Tapilskaya2Ivanovo State Medical AcademyMoscow Institute of Physics and Technology (State University), DolgoprudnySaint Petersburg State Pediatric Medical UniversitySystems biology analysis of over 700 magnesium-dependent proteins in human proteome shown that these proteins affect (1) the embryonic development, (2) energy metabolism, (3) signal transduction processes from receptors, (4) neurological function, (5) support of connective tissue structure, (6) cardiovascular and (7) immunological roles. Magnesium deficiency during pregnancy will stimulate development of congential malformations (skeletal defects, rickets, hernia of the diaphragm, facial defects, craniosynostosis, structural disorders of the retina and vision, brachydactyly). Magnesium deficiency at an early age is associated with sudden death syndrome in preschool and adolescence leads to impaired function of skeletal muscles and myocardium. Magnesium deficiency is also characterized by mitochondrial disorders, hyperinsulinemia, disorders of the skin structure and its appendages, tumors and diseases associated with impaired energy metabolism (including hypoparathyroidism and anemia). Effects of magnesium deficiency in children significantly heavier on the background of lack of vitamin B6 (pyridoxine). The results of proteomic analysis enable to point out the relevant molecular and physiological mechanisms of synergy between magnesium and pyridoxine. Overall, the results of the analysis indicate a very extensive area for the correction of magnesium and pyridoxine deficiency for the prevention and treatment of a wide range of diseases, from the period of fetal development and early childhood through adolescence.https://www.med-sovet.pro/jour/article/view/1680proteomicssystems biologymagnesiumembryochildrenadolescentsprevention of magnesium deficiencypyridoxine (vitamin b6) |
| spellingShingle | O. A. Gromova I. Yu. Torshin N. I. Tapilskaya Proteomic analysis of magnesium-dependent proteins and children’s health Медицинский совет proteomics systems biology magnesium embryo children adolescents prevention of magnesium deficiency pyridoxine (vitamin b6) |
| title | Proteomic analysis of magnesium-dependent proteins and children’s health |
| title_full | Proteomic analysis of magnesium-dependent proteins and children’s health |
| title_fullStr | Proteomic analysis of magnesium-dependent proteins and children’s health |
| title_full_unstemmed | Proteomic analysis of magnesium-dependent proteins and children’s health |
| title_short | Proteomic analysis of magnesium-dependent proteins and children’s health |
| title_sort | proteomic analysis of magnesium dependent proteins and children s health |
| topic | proteomics systems biology magnesium embryo children adolescents prevention of magnesium deficiency pyridoxine (vitamin b6) |
| url | https://www.med-sovet.pro/jour/article/view/1680 |
| work_keys_str_mv | AT oagromova proteomicanalysisofmagnesiumdependentproteinsandchildrenshealth AT iyutorshin proteomicanalysisofmagnesiumdependentproteinsandchildrenshealth AT nitapilskaya proteomicanalysisofmagnesiumdependentproteinsandchildrenshealth |