The rate and molecular spectrum of mutation are selectively maintained in yeast
How natural selection shapes the rate and molecular spectrum of mutations is debated. Yeast mutation accumulation experiments identify a gene promoting mutagenesis and show stabilizing selection maintaining the mutation rate above the drift barrier. Selection also preserves the mutation spectrum.
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24364-6 |
| _version_ | 1797850007393533952 |
|---|---|
| author | Haoxuan Liu Jianzhi Zhang |
| author_facet | Haoxuan Liu Jianzhi Zhang |
| author_sort | Haoxuan Liu |
| collection | DOAJ |
| description | How natural selection shapes the rate and molecular spectrum of mutations is debated. Yeast mutation accumulation experiments identify a gene promoting mutagenesis and show stabilizing selection maintaining the mutation rate above the drift barrier. Selection also preserves the mutation spectrum. |
| first_indexed | 2024-04-09T18:53:23Z |
| format | Article |
| id | doaj.art-fdcedfe9fd734fdf94a7c009e3c4b18e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T18:53:23Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-fdcedfe9fd734fdf94a7c009e3c4b18e2023-04-09T11:22:13ZengNature PortfolioNature Communications2041-17232021-06-0112111110.1038/s41467-021-24364-6The rate and molecular spectrum of mutation are selectively maintained in yeastHaoxuan Liu0Jianzhi Zhang1Department of Ecology and Evolutionary Biology, University of MichiganDepartment of Ecology and Evolutionary Biology, University of MichiganHow natural selection shapes the rate and molecular spectrum of mutations is debated. Yeast mutation accumulation experiments identify a gene promoting mutagenesis and show stabilizing selection maintaining the mutation rate above the drift barrier. Selection also preserves the mutation spectrum.https://doi.org/10.1038/s41467-021-24364-6 |
| spellingShingle | Haoxuan Liu Jianzhi Zhang The rate and molecular spectrum of mutation are selectively maintained in yeast Nature Communications |
| title | The rate and molecular spectrum of mutation are selectively maintained in yeast |
| title_full | The rate and molecular spectrum of mutation are selectively maintained in yeast |
| title_fullStr | The rate and molecular spectrum of mutation are selectively maintained in yeast |
| title_full_unstemmed | The rate and molecular spectrum of mutation are selectively maintained in yeast |
| title_short | The rate and molecular spectrum of mutation are selectively maintained in yeast |
| title_sort | rate and molecular spectrum of mutation are selectively maintained in yeast |
| url | https://doi.org/10.1038/s41467-021-24364-6 |
| work_keys_str_mv | AT haoxuanliu therateandmolecularspectrumofmutationareselectivelymaintainedinyeast AT jianzhizhang therateandmolecularspectrumofmutationareselectivelymaintainedinyeast AT haoxuanliu rateandmolecularspectrumofmutationareselectivelymaintainedinyeast AT jianzhizhang rateandmolecularspectrumofmutationareselectivelymaintainedinyeast |