A case of renal involvement in juvenile xanthogranulomatosis
Juvenile xanthogranuloma (JXG) is a type of non-Langerhans cell histiocytosis that rarely involves other than the skin. Here, we present detailed ultrasound (US) findings, including a contrast study, of a rare JXD renal lesion. A 42-year-old woman with JXG had chronic kidney disease. Ultrasound show...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043322009797 |
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| author | Saki Shibuki, MD Tsukasa Saida, MD Takashi Kamimaki, MT Yohei Takei, MD Shuya Kandori, MD Hiroyuki Nishiyama, MD Takahito Nakajima, MD |
| author_facet | Saki Shibuki, MD Tsukasa Saida, MD Takashi Kamimaki, MT Yohei Takei, MD Shuya Kandori, MD Hiroyuki Nishiyama, MD Takahito Nakajima, MD |
| author_sort | Saki Shibuki, MD |
| collection | DOAJ |
| description | Juvenile xanthogranuloma (JXG) is a type of non-Langerhans cell histiocytosis that rarely involves other than the skin. Here, we present detailed ultrasound (US) findings, including a contrast study, of a rare JXD renal lesion. A 42-year-old woman with JXG had chronic kidney disease. Ultrasound showed multiple cystic masses with fine internal septa in both kidneys. Contrast-enhanced US revealed early staining and late washout consistent with the internal septa inside the masses and led us to suspect cystic renal cell carcinomas in both kidneys. Left nephrectomy was performed for diagnostic purposes. Microscopic examination revealed a foamy component with Touton-type giant cells by histiocytosis; CD68 and S100 were positive, and CD1a was negative, leading the diagnosis of JXD. The US findings of extracutaneous lesions on JXA are variable and can be cystic, and when arising in the kidney may resemble cystic renal cell carcinoma. |
| first_indexed | 2024-04-11T13:12:08Z |
| format | Article |
| id | doaj.art-fdcfa073a17d4a6eb2505f1acc57f584 |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-04-11T13:12:08Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-fdcfa073a17d4a6eb2505f1acc57f5842022-12-22T04:22:34ZengElsevierRadiology Case Reports1930-04332023-02-01182460462A case of renal involvement in juvenile xanthogranulomatosisSaki Shibuki, MD0Tsukasa Saida, MD1Takashi Kamimaki, MT2Yohei Takei, MD3Shuya Kandori, MD4Hiroyuki Nishiyama, MD5Takahito Nakajima, MD6Department of Radiology, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki, Japan, 305-8576Department of Radiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan, 305-8575; Corresponding author.Department of Laboratory, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki, Japan, 305-8576Department of Radiology, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki, Japan, 305-8576Department of Urology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan, 305-8575Department of Urology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan, 305-8575Department of Radiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan, 305-8575Juvenile xanthogranuloma (JXG) is a type of non-Langerhans cell histiocytosis that rarely involves other than the skin. Here, we present detailed ultrasound (US) findings, including a contrast study, of a rare JXD renal lesion. A 42-year-old woman with JXG had chronic kidney disease. Ultrasound showed multiple cystic masses with fine internal septa in both kidneys. Contrast-enhanced US revealed early staining and late washout consistent with the internal septa inside the masses and led us to suspect cystic renal cell carcinomas in both kidneys. Left nephrectomy was performed for diagnostic purposes. Microscopic examination revealed a foamy component with Touton-type giant cells by histiocytosis; CD68 and S100 were positive, and CD1a was negative, leading the diagnosis of JXD. The US findings of extracutaneous lesions on JXA are variable and can be cystic, and when arising in the kidney may resemble cystic renal cell carcinoma.http://www.sciencedirect.com/science/article/pii/S1930043322009797Juvenile xanthogranulomaJXGUltrasoundMagnetic resonance imaging |
| spellingShingle | Saki Shibuki, MD Tsukasa Saida, MD Takashi Kamimaki, MT Yohei Takei, MD Shuya Kandori, MD Hiroyuki Nishiyama, MD Takahito Nakajima, MD A case of renal involvement in juvenile xanthogranulomatosis Radiology Case Reports Juvenile xanthogranuloma JXG Ultrasound Magnetic resonance imaging |
| title | A case of renal involvement in juvenile xanthogranulomatosis |
| title_full | A case of renal involvement in juvenile xanthogranulomatosis |
| title_fullStr | A case of renal involvement in juvenile xanthogranulomatosis |
| title_full_unstemmed | A case of renal involvement in juvenile xanthogranulomatosis |
| title_short | A case of renal involvement in juvenile xanthogranulomatosis |
| title_sort | case of renal involvement in juvenile xanthogranulomatosis |
| topic | Juvenile xanthogranuloma JXG Ultrasound Magnetic resonance imaging |
| url | http://www.sciencedirect.com/science/article/pii/S1930043322009797 |
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