Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease

Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease

Background: Recent studies have suggested that IgE sensitization to α-gal is associated with coronary artery disease (CAD). However, the B cell subtype(s) responsible for production of IgE to α-gal and mechanisms mediating this production remain elusive.Methods: Single cell multi-omics sequencing, w...

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Bibliographic Details
Main Authors: Tanyaporn Pattarabanjird, Jeffrey M. Wilson, Loren D. Erickson, Lisa J. Workman, Hui Qiao, Yanal Ghosheh, Rishab Gulati, Chistopher Durant, Jenifer Vallejo, Ryosuke Saigusa, Thomas A. E. Platts-Mills, Angela M. Taylor, Klaus Ley, Coleen A. McNamara
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
alpha-gal
B cells
coronary artery disease
IgE class switching
CITESeq
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.791028/full

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