Integrated cross-study datasets of genetic dependencies in cancer
The integration of independent pan-cancer CRISPR-Cas9 datasets allows better representation of genomic heterogeneity across different cancer types. Here, the authors propose a strategy for the integration of two large CRISPR-Cas9 screens and report increased coverage of molecular diversity and genet...
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Bibliographic Details
| Main Authors: |
Clare Pacini,
Joshua M. Dempster,
Isabella Boyle,
Emanuel Gonçalves,
Hanna Najgebauer,
Emre Karakoc,
Dieudonne van der Meer,
Andrew Barthorpe,
Howard Lightfoot,
Patricia Jaaks,
James M. McFarland,
Mathew J. Garnett,
Aviad Tsherniak,
Francesco Iorio |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-21898-7
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