Microenvironmental Determinants of Breast Cancer Metastasis: Focus on the Crucial Interplay Between Estrogen and Insulin/Insulin-Like Growth Factor Signaling

Microenvironmental Determinants of Breast Cancer Metastasis: Focus on the Crucial Interplay Between Estrogen and Insulin/Insulin-Like Growth Factor Signaling

The development and progression of the great majority of breast cancers (BCs) are mainly dependent on the biological action elicited by estrogens through the classical estrogen receptor (ER), as well as the alternate receptor named G-protein–coupled estrogen receptor (GPER). In addition to estrogens...

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Bibliographic Details
Main Authors: Veronica Vella, Ernestina Marianna De Francesco, Rosamaria Lappano, Maria Grazia Muoio, Livia Manzella, Marcello Maggiolini, Antonino Belfiore
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
breast cancer
metastasis
estrogen receptor
GPER
insulin/IGF signaling
tumor microenvionment
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.608412/full

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