Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism
The prevalence of metabolic syndrome (MetS) is drastically growing worldwide, resulting in MetS-associated kidney disease. According to traditional theories, preventing blood pressure, lipid, glycose, and obesity and improving insulin resistance (IR), a couple of medications are required for MetS. I...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1112088/full |
| _version_ | 1811170977664466944 |
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| author | Ya-Fei Liu Huan-Huan Wang Yin-Hong Geng Liang Han Sheng-Hao Tu Hui Wang |
| author_facet | Ya-Fei Liu Huan-Huan Wang Yin-Hong Geng Liang Han Sheng-Hao Tu Hui Wang |
| author_sort | Ya-Fei Liu |
| collection | DOAJ |
| description | The prevalence of metabolic syndrome (MetS) is drastically growing worldwide, resulting in MetS-associated kidney disease. According to traditional theories, preventing blood pressure, lipid, glycose, and obesity and improving insulin resistance (IR), a couple of medications are required for MetS. It not only lowers patients’ compliance but also elevates adverse reactions. Accordingly, we attempted to seek answers from complementary and alternative medicine. Ultimately, berberine (BBR) was chosen due to its efficacy and safety on MetS through multi-pathways and multi-targets. The effects and mechanisms of BBR on obesity, IR, diabetic nephropathy, hypertension, hyperlipidemia, and hyperuricemia were elaborated. In addition, the overall properties of BBR and interventions for various kidney diseases were also collected. However, more clinical trials are expected to further identify the beneficial effects of BBR. |
| first_indexed | 2024-04-10T17:05:47Z |
| format | Article |
| id | doaj.art-fdd31849b56042cdbb849c8889e33c37 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T17:05:47Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-fdd31849b56042cdbb849c8889e33c372023-02-06T05:58:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-02-011410.3389/fphar.2023.11120881112088Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanismYa-Fei Liu0Huan-Huan Wang1Yin-Hong Geng2Liang Han3Sheng-Hao Tu4Hui Wang5Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaNephrology Department of Integrated Traditional Chinese and Western Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, ChinaThe prevalence of metabolic syndrome (MetS) is drastically growing worldwide, resulting in MetS-associated kidney disease. According to traditional theories, preventing blood pressure, lipid, glycose, and obesity and improving insulin resistance (IR), a couple of medications are required for MetS. It not only lowers patients’ compliance but also elevates adverse reactions. Accordingly, we attempted to seek answers from complementary and alternative medicine. Ultimately, berberine (BBR) was chosen due to its efficacy and safety on MetS through multi-pathways and multi-targets. The effects and mechanisms of BBR on obesity, IR, diabetic nephropathy, hypertension, hyperlipidemia, and hyperuricemia were elaborated. In addition, the overall properties of BBR and interventions for various kidney diseases were also collected. However, more clinical trials are expected to further identify the beneficial effects of BBR.https://www.frontiersin.org/articles/10.3389/fphar.2023.1112088/fullberberinemetabolic syndromeobesitydiabetic nephropathyinsulin resistancehyperlipidemia |
| spellingShingle | Ya-Fei Liu Huan-Huan Wang Yin-Hong Geng Liang Han Sheng-Hao Tu Hui Wang Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism Frontiers in Pharmacology berberine metabolic syndrome obesity diabetic nephropathy insulin resistance hyperlipidemia |
| title | Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism |
| title_full | Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism |
| title_fullStr | Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism |
| title_full_unstemmed | Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism |
| title_short | Advances of berberine against metabolic syndrome-associated kidney disease: Regarding effect and mechanism |
| title_sort | advances of berberine against metabolic syndrome associated kidney disease regarding effect and mechanism |
| topic | berberine metabolic syndrome obesity diabetic nephropathy insulin resistance hyperlipidemia |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1112088/full |
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