Olfactory impairment in Wilson’s disease
Abstract Introduction Olfactory dysfunction is a common and early sign of many neurodegenerative disorders, but little is known about olfactory dysfunction in Wilson’s disease (WD). We aimed to evaluate olfactory function in patients with WD and identify selective WD screening odors. Methods We meas...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-03-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2022 |
| _version_ | 1818859368762834944 |
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| author | Lei Chen Xin Wang Richard L. Doty Shanshan Cao Junxiu Yang Feng Sun Xiaoyan Yan |
| author_facet | Lei Chen Xin Wang Richard L. Doty Shanshan Cao Junxiu Yang Feng Sun Xiaoyan Yan |
| author_sort | Lei Chen |
| collection | DOAJ |
| description | Abstract Introduction Olfactory dysfunction is a common and early sign of many neurodegenerative disorders, but little is known about olfactory dysfunction in Wilson’s disease (WD). We aimed to evaluate olfactory function in patients with WD and identify selective WD screening odors. Methods We measured olfactory identification ability in 25 patients with WD and 25 healthy controls using the University of Pennsylvania Smell Identification Test (UPSIT). Patients with WD were evaluated using the Global Assessment Scale for WD (GAS). Cognitive function was measured using the Mini–Mental State Examination. Results Patients with WD were worse at identifying smells in the simplified Chinese version of the UPSIT compared with healthy controls (t = 2.198, p = .033), but there was no difference in olfactory dysfunction severity between the groups (V = 136, p = .094). UPSIT scores negatively correlated with the GAS neurological scores in patients with WD (r = −0.571, p = .003). Using logistic regression with least absolute shrinkage and selection operator analysis, two models were screened. Receiver‐operating characteristic (ROC) curve analysis revealed that, to discriminate WD patients from healthy controls, the area under the ROC curve (AUC) for a combination of seven odors (motor oil, onion, licorice, strawberry, tire, jasmine, and natural gas) was 0.926, while the AUC for three odors (onion, licorice, and jasmine) was 0.852. Conclusions Patients with WD may have stable, selective olfactory impairments. This selective pattern may be a useful tool for disease diagnosis and prediction. |
| first_indexed | 2024-12-19T09:11:05Z |
| format | Article |
| id | doaj.art-fdd36e74e46b45aebdb6fe8d811552ac |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-19T09:11:05Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-fdd36e74e46b45aebdb6fe8d811552ac2022-12-21T20:28:11ZengWileyBrain and Behavior2162-32792021-03-01113n/an/a10.1002/brb3.2022Olfactory impairment in Wilson’s diseaseLei Chen0Xin Wang1Richard L. Doty2Shanshan Cao3Junxiu Yang4Feng Sun5Xiaoyan Yan6Department of Neurology Tianjin Huan Hu Hospital Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases Tianjin ChinaDepartment of Neurology Tianjin Huan Hu Hospital Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases Tianjin ChinaSmell and Taste Center Perelman School of Medicine University of Pennsylvania Philadelphia PA USADepartment of Gerontology The No. 2 Hospital of Baoding Baoding ChinaDepartment of Neurology Hebei Petro China Central Hospital Langfang ChinaDepartment of Neurology Tianjin Medical University General Hospital Tianjin ChinaPeking University Clinical Research Institute Peking University First Hospital Beijing ChinaAbstract Introduction Olfactory dysfunction is a common and early sign of many neurodegenerative disorders, but little is known about olfactory dysfunction in Wilson’s disease (WD). We aimed to evaluate olfactory function in patients with WD and identify selective WD screening odors. Methods We measured olfactory identification ability in 25 patients with WD and 25 healthy controls using the University of Pennsylvania Smell Identification Test (UPSIT). Patients with WD were evaluated using the Global Assessment Scale for WD (GAS). Cognitive function was measured using the Mini–Mental State Examination. Results Patients with WD were worse at identifying smells in the simplified Chinese version of the UPSIT compared with healthy controls (t = 2.198, p = .033), but there was no difference in olfactory dysfunction severity between the groups (V = 136, p = .094). UPSIT scores negatively correlated with the GAS neurological scores in patients with WD (r = −0.571, p = .003). Using logistic regression with least absolute shrinkage and selection operator analysis, two models were screened. Receiver‐operating characteristic (ROC) curve analysis revealed that, to discriminate WD patients from healthy controls, the area under the ROC curve (AUC) for a combination of seven odors (motor oil, onion, licorice, strawberry, tire, jasmine, and natural gas) was 0.926, while the AUC for three odors (onion, licorice, and jasmine) was 0.852. Conclusions Patients with WD may have stable, selective olfactory impairments. This selective pattern may be a useful tool for disease diagnosis and prediction.https://doi.org/10.1002/brb3.2022diagnosisolfactory functionWilson’s disease |
| spellingShingle | Lei Chen Xin Wang Richard L. Doty Shanshan Cao Junxiu Yang Feng Sun Xiaoyan Yan Olfactory impairment in Wilson’s disease Brain and Behavior diagnosis olfactory function Wilson’s disease |
| title | Olfactory impairment in Wilson’s disease |
| title_full | Olfactory impairment in Wilson’s disease |
| title_fullStr | Olfactory impairment in Wilson’s disease |
| title_full_unstemmed | Olfactory impairment in Wilson’s disease |
| title_short | Olfactory impairment in Wilson’s disease |
| title_sort | olfactory impairment in wilson s disease |
| topic | diagnosis olfactory function Wilson’s disease |
| url | https://doi.org/10.1002/brb3.2022 |
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