Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

Robust T cell activation requires an eIF3-driven burst in T cell receptor translation

Activation of T cells requires a rapid surge in cellular protein synthesis. However, the role of translation initiation in the early induction of specific genes remains unclear. Here, we show human translation initiation factor eIF3 interacts with select immune system related mRNAs including those e...

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Bibliographic Details
Main Authors: Dasmanthie De Silva, Lucas Ferguson, Grant H Chin, Benjamin E Smith, Ryan A Apathy, Theodore L Roth, Franziska Blaeschke, Marek Kudla, Alexander Marson, Nicholas T Ingolia, Jamie HD Cate
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
eIF3
protein synthesis
T cell receptor
CD28
chimeric antigen receptor
cellular immunotherapy
Online Access:https://elifesciences.org/articles/74272

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