Enzymes and cytokines disease in total hip arthroplasty: promoters of immune loosening
Introduction: An important cause of hip prosthesis failure is loosening related to cytokine-mediated release of enzymes that produces lysis of the bone that supports the implant. Objective: This paper aims to describe the biological interaction mechanisms of the molecules that promote total hip pros...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2018-07-01
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| Series: | Revista de la Facultad de Medicina |
| Subjects: | |
| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/61525 |
| _version_ | 1811282852774412288 |
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| author | Victorino Pacheco-Martelo Sebastián Roldán-Vasco |
| author_facet | Victorino Pacheco-Martelo Sebastián Roldán-Vasco |
| author_sort | Victorino Pacheco-Martelo |
| collection | DOAJ |
| description | Introduction: An important cause of hip prosthesis failure is loosening related to cytokine-mediated release of enzymes that produces lysis of the bone that supports the implant.
Objective: This paper aims to describe the biological interaction mechanisms of the molecules that promote total hip prosthesis loosening, the most frequent problem observed during the process.
Materials and methods: The authors conducted a literature search in the PubMed and Scopus databases for original articles and clinical cases with no filters by publication date. MeSH terms hip prosthesis loosening, aseptic loosening, cytokines, and hip arthroplasty failure were used. Data were extracted from 250 studies, of which 66 were representative for this review and were selected for writing purposes.
Results: The most representative molecules involved in hip prosthesis loosening are described, and the interactions between them are presented.
Conclusions: Enzymes and cytokines have been widely studied for four decades, although their interaction mechanisms are still misunderstood. In consequence, an interaction mechanism, which may be called “enzymes and cytokines disease” or “immune loosening”, is proposed. |
| first_indexed | 2024-04-13T02:00:00Z |
| format | Article |
| id | doaj.art-fdd45dcbf6e647fda7fc481afefcad9d |
| institution | Directory Open Access Journal |
| issn | 0120-0011 2357-3848 |
| language | English |
| last_indexed | 2024-04-13T02:00:00Z |
| publishDate | 2018-07-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Revista de la Facultad de Medicina |
| spelling | doaj.art-fdd45dcbf6e647fda7fc481afefcad9d2022-12-22T03:07:39ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482018-07-0166347748410.15446/revfacmed.v66n3.6152549309Enzymes and cytokines disease in total hip arthroplasty: promoters of immune looseningVictorino Pacheco-Martelo0Sebastián Roldán-Vasco1Clínica Las Vegas - Joint Replacement Group - Medellín, Colombia. Universidad de Antioquia - Faculty of Medicine - Medellín - Colombia.Instituto Tecnológico Metropolitano - Faculty of Engineering - Research Group in Advanced Materials and Energy - Medellín- Colombia.Introduction: An important cause of hip prosthesis failure is loosening related to cytokine-mediated release of enzymes that produces lysis of the bone that supports the implant. Objective: This paper aims to describe the biological interaction mechanisms of the molecules that promote total hip prosthesis loosening, the most frequent problem observed during the process. Materials and methods: The authors conducted a literature search in the PubMed and Scopus databases for original articles and clinical cases with no filters by publication date. MeSH terms hip prosthesis loosening, aseptic loosening, cytokines, and hip arthroplasty failure were used. Data were extracted from 250 studies, of which 66 were representative for this review and were selected for writing purposes. Results: The most representative molecules involved in hip prosthesis loosening are described, and the interactions between them are presented. Conclusions: Enzymes and cytokines have been widely studied for four decades, although their interaction mechanisms are still misunderstood. In consequence, an interaction mechanism, which may be called “enzymes and cytokines disease” or “immune loosening”, is proposed.https://revistas.unal.edu.co/index.php/revfacmed/article/view/61525Hip ProsthesisHip Replacement ArthroplastyProsthesis FailureCytokinesGraft Rejection |
| spellingShingle | Victorino Pacheco-Martelo Sebastián Roldán-Vasco Enzymes and cytokines disease in total hip arthroplasty: promoters of immune loosening Revista de la Facultad de Medicina Hip Prosthesis Hip Replacement Arthroplasty Prosthesis Failure Cytokines Graft Rejection |
| title | Enzymes and cytokines disease in total hip arthroplasty: promoters of immune loosening |
| title_full | Enzymes and cytokines disease in total hip arthroplasty: promoters of immune loosening |
| title_fullStr | Enzymes and cytokines disease in total hip arthroplasty: promoters of immune loosening |
| title_full_unstemmed | Enzymes and cytokines disease in total hip arthroplasty: promoters of immune loosening |
| title_short | Enzymes and cytokines disease in total hip arthroplasty: promoters of immune loosening |
| title_sort | enzymes and cytokines disease in total hip arthroplasty promoters of immune loosening |
| topic | Hip Prosthesis Hip Replacement Arthroplasty Prosthesis Failure Cytokines Graft Rejection |
| url | https://revistas.unal.edu.co/index.php/revfacmed/article/view/61525 |
| work_keys_str_mv | AT victorinopachecomartelo enzymesandcytokinesdiseaseintotalhiparthroplastypromotersofimmuneloosening AT sebastianroldanvasco enzymesandcytokinesdiseaseintotalhiparthroplastypromotersofimmuneloosening |