Structural basis for the modulation of MRP2 activity by phosphorylation and drugs

Structural basis for the modulation of MRP2 activity by phosphorylation and drugs

Abstract Multidrug resistance-associated protein 2 (MRP2/ABCC2) is a polyspecific efflux transporter of organic anions expressed in hepatocyte canalicular membranes. MRP2 dysfunction, in Dubin-Johnson syndrome or by off-target inhibition, for example by the uricosuric drug probenecid, elevates circu...

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Bibliographic Details
Main Authors: Tiziano Mazza, Theodoros I. Roumeliotis, Elena Garitta, David Drew, S. Tamir Rashid, Cesare Indiveri, Jyoti S. Choudhary, Kenneth J. Linton, Konstantinos Beis
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46392-8

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https://doi.org/10.1038/s41467-024-46392-8

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