Efficacy of Non-Invasive Brain Stimulation for Refractory Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Controlled Trials
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder, with 30–40% of OCD patients being unresponsive to adequate trials of anti-OCD drugs and cognitive behavior therapy. The aim of this paper is to investigate the efficacy of non-invasive brain stimulation (NIBS) on treating refractory...
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MDPI AG
2022-07-01
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| Online Access: | https://www.mdpi.com/2076-3425/12/7/943 |
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| author | Shu Zhou Yan Fang |
| author_facet | Shu Zhou Yan Fang |
| author_sort | Shu Zhou |
| collection | DOAJ |
| description | Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder, with 30–40% of OCD patients being unresponsive to adequate trials of anti-OCD drugs and cognitive behavior therapy. The aim of this paper is to investigate the efficacy of non-invasive brain stimulation (NIBS) on treating refractory OCD. With PubMed, Embase, PsycInfo, and Cochrane Library used on 15 February 2022, 24 randomized controlled trials involving 663 patients were included. According to this analysis, NIBS including repetitive transcranial magnetic stimulation (rTMS), theta-burst stimulation (TBS), and transcranial direct current stimulation (tDCS), had a moderate effect on the reduction of Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores (SMD = 0.54, 95% CI: 0.26–0.81; <i>p</i> < 0.01). In the subgroup analysis, rTMS seemed to produce a better therapeutic effect (SMD = 0.73, 95% CI: 0.38–1.08; <i>p</i> < 0.01). Moreover, excitatory (SMD = 1.13, 95% CI: 0.24–2.01; <i>p</i> = 0.01) and inhibitory (SMD = 0.81, 95% CI: 0.26–1.36; <i>p</i> < 0.01) stimulation of the dorsolateral prefrontal cortex (DLPFC) both alleviated OCD symptoms. In the secondary outcome of clinical response rates, NIBS treatment led to an increase in response rates (RR = 2.26, 95% CI: 1.57–3.25; <i>p</i> < 0.01). |
| first_indexed | 2024-03-09T12:10:12Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T12:10:12Z |
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| series | Brain Sciences |
| spelling | doaj.art-fdd63e6a7127488096ed9eaf8c5bc2432023-11-30T22:54:19ZengMDPI AGBrain Sciences2076-34252022-07-0112794310.3390/brainsci12070943Efficacy of Non-Invasive Brain Stimulation for Refractory Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Controlled TrialsShu Zhou0Yan Fang1The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaDepartment of Physiology, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaObsessive-compulsive disorder (OCD) is a neuropsychiatric disorder, with 30–40% of OCD patients being unresponsive to adequate trials of anti-OCD drugs and cognitive behavior therapy. The aim of this paper is to investigate the efficacy of non-invasive brain stimulation (NIBS) on treating refractory OCD. With PubMed, Embase, PsycInfo, and Cochrane Library used on 15 February 2022, 24 randomized controlled trials involving 663 patients were included. According to this analysis, NIBS including repetitive transcranial magnetic stimulation (rTMS), theta-burst stimulation (TBS), and transcranial direct current stimulation (tDCS), had a moderate effect on the reduction of Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores (SMD = 0.54, 95% CI: 0.26–0.81; <i>p</i> < 0.01). In the subgroup analysis, rTMS seemed to produce a better therapeutic effect (SMD = 0.73, 95% CI: 0.38–1.08; <i>p</i> < 0.01). Moreover, excitatory (SMD = 1.13, 95% CI: 0.24–2.01; <i>p</i> = 0.01) and inhibitory (SMD = 0.81, 95% CI: 0.26–1.36; <i>p</i> < 0.01) stimulation of the dorsolateral prefrontal cortex (DLPFC) both alleviated OCD symptoms. In the secondary outcome of clinical response rates, NIBS treatment led to an increase in response rates (RR = 2.26, 95% CI: 1.57–3.25; <i>p</i> < 0.01).https://www.mdpi.com/2076-3425/12/7/943refractory obsessive-compulsive disordernon-invasive brain stimulationrepetitive transcranial magnetic stimulationtheta-burst stimulationtranscranial direct current stimulationmeta-analysis |
| spellingShingle | Shu Zhou Yan Fang Efficacy of Non-Invasive Brain Stimulation for Refractory Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Controlled Trials Brain Sciences refractory obsessive-compulsive disorder non-invasive brain stimulation repetitive transcranial magnetic stimulation theta-burst stimulation transcranial direct current stimulation meta-analysis |
| title | Efficacy of Non-Invasive Brain Stimulation for Refractory Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Controlled Trials |
| title_full | Efficacy of Non-Invasive Brain Stimulation for Refractory Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Efficacy of Non-Invasive Brain Stimulation for Refractory Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Efficacy of Non-Invasive Brain Stimulation for Refractory Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Controlled Trials |
| title_short | Efficacy of Non-Invasive Brain Stimulation for Refractory Obsessive-Compulsive Disorder: A Meta-Analysis of Randomized Controlled Trials |
| title_sort | efficacy of non invasive brain stimulation for refractory obsessive compulsive disorder a meta analysis of randomized controlled trials |
| topic | refractory obsessive-compulsive disorder non-invasive brain stimulation repetitive transcranial magnetic stimulation theta-burst stimulation transcranial direct current stimulation meta-analysis |
| url | https://www.mdpi.com/2076-3425/12/7/943 |
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