Cardiovascular control in experimental diabetes
Several studies have reported impairment in cardiovascular function and control in diabetes. The studies cited in this review were carried out from a few days up to 3 months after streptozotocin administration and were concerned with the control of the circulation. We observed that early changes (5...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2002-09-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900010 |
| _version_ | 1811202341102157824 |
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| author | K. De Angelis B.D. Schaan C.Y. Maeda P. Dall'Ago R.B. Wichi M.C. Irigoyen |
| author_facet | K. De Angelis B.D. Schaan C.Y. Maeda P. Dall'Ago R.B. Wichi M.C. Irigoyen |
| author_sort | K. De Angelis |
| collection | DOAJ |
| description | Several studies have reported impairment in cardiovascular function and control in diabetes. The studies cited in this review were carried out from a few days up to 3 months after streptozotocin administration and were concerned with the control of the circulation. We observed that early changes (5 days) in blood pressure control by different peripheral receptors were maintained for several months. Moreover, the impairment of reflex responses observed after baroreceptor and chemoreceptor stimulation was probably related to changes in the efferent limb of the reflex arc (sympathetic and parasympathetic), but changes also in the central nervous system could not be excluded. Changes in renal sympathetic nerve activity during volume expansion were blunted in streptozotocin-treated rats, indicating an adaptive natriuretic and diuretic response in the diabetic state. The improvement of diabetic cardiovascular dysfunction induced by exercise training seems to be related to changes in the autonomic nervous system. Complementary studies about the complex interaction between circulation control systems are clearly needed to adequately address the management of pathophysiological changes associated with diabetes. |
| first_indexed | 2024-04-12T02:38:13Z |
| format | Article |
| id | doaj.art-fdd78f99c2db4c19a8d3a08325554ddd |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-12T02:38:13Z |
| publishDate | 2002-09-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-fdd78f99c2db4c19a8d3a08325554ddd2022-12-22T03:51:27ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2002-09-013591091110010.1590/S0100-879X2002000900010Cardiovascular control in experimental diabetesK. De AngelisB.D. SchaanC.Y. MaedaP. Dall'AgoR.B. WichiM.C. IrigoyenSeveral studies have reported impairment in cardiovascular function and control in diabetes. The studies cited in this review were carried out from a few days up to 3 months after streptozotocin administration and were concerned with the control of the circulation. We observed that early changes (5 days) in blood pressure control by different peripheral receptors were maintained for several months. Moreover, the impairment of reflex responses observed after baroreceptor and chemoreceptor stimulation was probably related to changes in the efferent limb of the reflex arc (sympathetic and parasympathetic), but changes also in the central nervous system could not be excluded. Changes in renal sympathetic nerve activity during volume expansion were blunted in streptozotocin-treated rats, indicating an adaptive natriuretic and diuretic response in the diabetic state. The improvement of diabetic cardiovascular dysfunction induced by exercise training seems to be related to changes in the autonomic nervous system. Complementary studies about the complex interaction between circulation control systems are clearly needed to adequately address the management of pathophysiological changes associated with diabetes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900010Experimental diabetesArterial pressureAutonomic controlBaroreflexChemoreflexCardiopulmonary reflexExercise training |
| spellingShingle | K. De Angelis B.D. Schaan C.Y. Maeda P. Dall'Ago R.B. Wichi M.C. Irigoyen Cardiovascular control in experimental diabetes Brazilian Journal of Medical and Biological Research Experimental diabetes Arterial pressure Autonomic control Baroreflex Chemoreflex Cardiopulmonary reflex Exercise training |
| title | Cardiovascular control in experimental diabetes |
| title_full | Cardiovascular control in experimental diabetes |
| title_fullStr | Cardiovascular control in experimental diabetes |
| title_full_unstemmed | Cardiovascular control in experimental diabetes |
| title_short | Cardiovascular control in experimental diabetes |
| title_sort | cardiovascular control in experimental diabetes |
| topic | Experimental diabetes Arterial pressure Autonomic control Baroreflex Chemoreflex Cardiopulmonary reflex Exercise training |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900010 |
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