The role of AGG interruptions in the transcription of FMR1 premutation alleles.

The role of AGG interruptions in the transcription of FMR1 premutation alleles.

Fragile X associated disorders are caused by a premutation allele in the fragile X mental retardation 1 gene (FMR1) and are hypothesized to result from the toxic effect of elevated levels of expanded FMR1 transcripts. Increased levels of FMR1 mRNA have indeed been reported in premutation carriers; h...

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Bibliographic Details
Main Authors: Carolyn M Yrigollen, Federica Tassone, Blythe Durbin-Johnson, Flora Tassone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3139575?pdf=render

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