A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration
The degeneration of axons and their terminals occurs following traumatic, toxic, or genetically-induced insults. Common molecular mechanisms unite these disparate triggers to execute a conserved nerve degeneration cascade. In this review, we will discuss how models of peripheral nerve injury and neu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1166146/full |
| _version_ | 1827874749177397248 |
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| author | Martha R. C. Bhattacharya |
| author_facet | Martha R. C. Bhattacharya |
| author_sort | Martha R. C. Bhattacharya |
| collection | DOAJ |
| description | The degeneration of axons and their terminals occurs following traumatic, toxic, or genetically-induced insults. Common molecular mechanisms unite these disparate triggers to execute a conserved nerve degeneration cascade. In this review, we will discuss how models of peripheral nerve injury and neuropathy in Drosophila have led the way in advancing molecular understanding of axon degeneration and nerve injury pathways. Both neuron-intrinsic as well as glial responses to injury will be highlighted. Finally, we will offer perspective on what additional questions should be answered to advance these discoveries toward clinical interventions for patients with neuropathy. |
| first_indexed | 2024-03-12T16:57:18Z |
| format | Article |
| id | doaj.art-fdd9681125d84cc391791ab0ac32a8b0 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-12T16:57:18Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-fdd9681125d84cc391791ab0ac32a8b02023-08-08T06:08:15ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-08-011510.3389/fnagi.2023.11661461166146A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degenerationMartha R. C. BhattacharyaThe degeneration of axons and their terminals occurs following traumatic, toxic, or genetically-induced insults. Common molecular mechanisms unite these disparate triggers to execute a conserved nerve degeneration cascade. In this review, we will discuss how models of peripheral nerve injury and neuropathy in Drosophila have led the way in advancing molecular understanding of axon degeneration and nerve injury pathways. Both neuron-intrinsic as well as glial responses to injury will be highlighted. Finally, we will offer perspective on what additional questions should be answered to advance these discoveries toward clinical interventions for patients with neuropathy.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1166146/fullDrosophilaperipheral neuropathyaxon degenerationALSCharcot-Marie Tooth disease |
| spellingShingle | Martha R. C. Bhattacharya A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration Frontiers in Aging Neuroscience Drosophila peripheral neuropathy axon degeneration ALS Charcot-Marie Tooth disease |
| title | A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration |
| title_full | A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration |
| title_fullStr | A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration |
| title_full_unstemmed | A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration |
| title_short | A nerve-wracking buzz: lessons from Drosophila models of peripheral neuropathy and axon degeneration |
| title_sort | nerve wracking buzz lessons from drosophila models of peripheral neuropathy and axon degeneration |
| topic | Drosophila peripheral neuropathy axon degeneration ALS Charcot-Marie Tooth disease |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1166146/full |
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