Emerging role of Protein Kinase CK2 in Tumor immunity
Protein kinase CK2, a conserved serine/threonine-protein kinase, is ubiquitous in cells and regulates various intracellular processes, especially in tumor cells. As one of the earliest discovered protein kinases in humans, CK2 plays a crucial role in phosphorylating or associating with hundreds of s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1065027/full |
| _version_ | 1797987467476860928 |
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| author | Leichong Chen Sijia Zhang Qianwen Li Junyu Li Huilin Deng Sheng Zhang Rui Meng |
| author_facet | Leichong Chen Sijia Zhang Qianwen Li Junyu Li Huilin Deng Sheng Zhang Rui Meng |
| author_sort | Leichong Chen |
| collection | DOAJ |
| description | Protein kinase CK2, a conserved serine/threonine-protein kinase, is ubiquitous in cells and regulates various intracellular processes, especially in tumor cells. As one of the earliest discovered protein kinases in humans, CK2 plays a crucial role in phosphorylating or associating with hundreds of substrates to modulate several signaling pathways. Excellent reviews have reported that the overexpression of CK2 could be observed in many cancers and was closely associated with tumor occurrence and development. The elevation of CK2 is also an indicator of a poor prognosis. Recently, increasing attention has been paid to the relationship between CK2 and tumor immunity. However, there is no comprehensive description of how CK2 regulates the immune cells in the tumor microenvironment (TME). Also, the underlying mechanisms are still not very clear. In this review, we systematically summarized the correlation between CK2 and tumor immunity, primarily the effects on various immune cells, both in innate and adaptive immunity in the TME. With the comprehensive development of immunotherapy and the mounting transformation research of CK2 inhibitors from the bench to the clinic, this review will provide vital information to find new treatment options for enhancing the efficacy of immunotherapy. |
| first_indexed | 2024-04-11T07:48:57Z |
| format | Article |
| id | doaj.art-fddcedf3c4654d7ca4803898443082fc |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T07:48:57Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-fddcedf3c4654d7ca4803898443082fc2022-12-22T04:36:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10650271065027Emerging role of Protein Kinase CK2 in Tumor immunityLeichong Chen0Sijia Zhang1Qianwen Li2Junyu Li3Huilin Deng4Sheng Zhang5Rui Meng6Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaProtein kinase CK2, a conserved serine/threonine-protein kinase, is ubiquitous in cells and regulates various intracellular processes, especially in tumor cells. As one of the earliest discovered protein kinases in humans, CK2 plays a crucial role in phosphorylating or associating with hundreds of substrates to modulate several signaling pathways. Excellent reviews have reported that the overexpression of CK2 could be observed in many cancers and was closely associated with tumor occurrence and development. The elevation of CK2 is also an indicator of a poor prognosis. Recently, increasing attention has been paid to the relationship between CK2 and tumor immunity. However, there is no comprehensive description of how CK2 regulates the immune cells in the tumor microenvironment (TME). Also, the underlying mechanisms are still not very clear. In this review, we systematically summarized the correlation between CK2 and tumor immunity, primarily the effects on various immune cells, both in innate and adaptive immunity in the TME. With the comprehensive development of immunotherapy and the mounting transformation research of CK2 inhibitors from the bench to the clinic, this review will provide vital information to find new treatment options for enhancing the efficacy of immunotherapy.https://www.frontiersin.org/articles/10.3389/fonc.2022.1065027/fullprotein kinase CK2tumor immunity and immunotherapytumor microenvirenmentPD-L1signal pathway |
| spellingShingle | Leichong Chen Sijia Zhang Qianwen Li Junyu Li Huilin Deng Sheng Zhang Rui Meng Emerging role of Protein Kinase CK2 in Tumor immunity Frontiers in Oncology protein kinase CK2 tumor immunity and immunotherapy tumor microenvirenment PD-L1 signal pathway |
| title | Emerging role of Protein Kinase CK2 in Tumor immunity |
| title_full | Emerging role of Protein Kinase CK2 in Tumor immunity |
| title_fullStr | Emerging role of Protein Kinase CK2 in Tumor immunity |
| title_full_unstemmed | Emerging role of Protein Kinase CK2 in Tumor immunity |
| title_short | Emerging role of Protein Kinase CK2 in Tumor immunity |
| title_sort | emerging role of protein kinase ck2 in tumor immunity |
| topic | protein kinase CK2 tumor immunity and immunotherapy tumor microenvirenment PD-L1 signal pathway |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1065027/full |
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