Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma.

Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma.

Genomic analysis of human hepatocellular carcinoma (HCC) is potentially confounded by the differentiation state of the hepatic cell-of-origin. Here we integrated genomic analysis of mouse HCC (with defined cell-of-origin) along with normal development. We found a major shift in expression of Wnt and...

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Bibliographic Details
Main Authors: Jinyu Li, Maia Chanrion, Eric Sawey, Tim Wang, Edward Chow, Aaron Tward, Yi Su, Wen Xue, Robert Lucito, Lars Zender, Scott W Lowe, J Michael Bishop, Scott Powers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4349704?pdf=render

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