Expression of S100A16 Is Associated with Biological Aggressiveness and Poor Prognosis in Patients with Bladder Cancer Who Underwent Radical Cystectomy
S100 calcium binding protein A16 (S100A16) is expressed in various cancers; however, there are few reports on S100A16 in bladder cancer (BC). We retrospectively investigated clinical data including clinicopathological features in 121 patients with BC who underwent radical cystectomy (RC). Immunohist...
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/19/14536 |
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| author | Hiroki Katsumata Kazumasa Matsumoto Kengo Yanagita Yuriko Shimizu Shuhei Hirano Kazuki Kitajima Dai Koguchi Masaomi Ikeda Yuichi Sato Masatsugu Iwamura |
| author_facet | Hiroki Katsumata Kazumasa Matsumoto Kengo Yanagita Yuriko Shimizu Shuhei Hirano Kazuki Kitajima Dai Koguchi Masaomi Ikeda Yuichi Sato Masatsugu Iwamura |
| author_sort | Hiroki Katsumata |
| collection | DOAJ |
| description | S100 calcium binding protein A16 (S100A16) is expressed in various cancers; however, there are few reports on S100A16 in bladder cancer (BC). We retrospectively investigated clinical data including clinicopathological features in 121 patients with BC who underwent radical cystectomy (RC). Immunohistochemical staining was performed to evaluate S100A16 expression in archived specimens. Cases with >5% expression and more than moderate staining intensity on cancer cells were considered positive. S100A16 expression was observed in 54 patients (44.6%). Univariate analysis showed that S100A16 expression was significantly associated with age, pT stage, recurrence, and cancer-specific death. Kaplan–Meier analyses showed that patients with S100A16 expression had shorter overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) than those without S100A16 expression. In multivariate analysis, pT stage was an independent prognostic factor for OS and lymph node metastasis for CSS and RFS. S100A16 expression may be a biomarker of a biologically aggressive phenotype and poor prognosis in patients with BC who underwent RC. The PI3k/Akt signaling pathway is probably associated with S100A16 and may be a therapeutic target. |
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| id | doaj.art-fddd5886e9bf46f38adfd2cd14d84cb4 |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T21:44:17Z |
| publishDate | 2023-09-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fddd5886e9bf46f38adfd2cd14d84cb42023-11-19T14:28:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124191453610.3390/ijms241914536Expression of S100A16 Is Associated with Biological Aggressiveness and Poor Prognosis in Patients with Bladder Cancer Who Underwent Radical CystectomyHiroki Katsumata0Kazumasa Matsumoto1Kengo Yanagita2Yuriko Shimizu3Shuhei Hirano4Kazuki Kitajima5Dai Koguchi6Masaomi Ikeda7Yuichi Sato8Masatsugu Iwamura9Department of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, JapanDepartment of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, JapanBiofluid Biomarker Center, Niigata University, 8050 ikarashi 2-no-cho, Nishi-ku, Niigata 950-2181, Niigata, JapanDepartment of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, JapanDepartment of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, JapanDepartment of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, JapanDepartment of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, JapanDepartment of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, JapanDepartment of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, JapanDepartment of Urology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara 252-0374, Kanagawa, JapanS100 calcium binding protein A16 (S100A16) is expressed in various cancers; however, there are few reports on S100A16 in bladder cancer (BC). We retrospectively investigated clinical data including clinicopathological features in 121 patients with BC who underwent radical cystectomy (RC). Immunohistochemical staining was performed to evaluate S100A16 expression in archived specimens. Cases with >5% expression and more than moderate staining intensity on cancer cells were considered positive. S100A16 expression was observed in 54 patients (44.6%). Univariate analysis showed that S100A16 expression was significantly associated with age, pT stage, recurrence, and cancer-specific death. Kaplan–Meier analyses showed that patients with S100A16 expression had shorter overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) than those without S100A16 expression. In multivariate analysis, pT stage was an independent prognostic factor for OS and lymph node metastasis for CSS and RFS. S100A16 expression may be a biomarker of a biologically aggressive phenotype and poor prognosis in patients with BC who underwent RC. The PI3k/Akt signaling pathway is probably associated with S100A16 and may be a therapeutic target.https://www.mdpi.com/1422-0067/24/19/14536bladder cancercystectomyS100A16 proteinAHNAK nucleoprotein 2urothelial carcinomaimmunohistochemistry |
| spellingShingle | Hiroki Katsumata Kazumasa Matsumoto Kengo Yanagita Yuriko Shimizu Shuhei Hirano Kazuki Kitajima Dai Koguchi Masaomi Ikeda Yuichi Sato Masatsugu Iwamura Expression of S100A16 Is Associated with Biological Aggressiveness and Poor Prognosis in Patients with Bladder Cancer Who Underwent Radical Cystectomy International Journal of Molecular Sciences bladder cancer cystectomy S100A16 protein AHNAK nucleoprotein 2 urothelial carcinoma immunohistochemistry |
| title | Expression of S100A16 Is Associated with Biological Aggressiveness and Poor Prognosis in Patients with Bladder Cancer Who Underwent Radical Cystectomy |
| title_full | Expression of S100A16 Is Associated with Biological Aggressiveness and Poor Prognosis in Patients with Bladder Cancer Who Underwent Radical Cystectomy |
| title_fullStr | Expression of S100A16 Is Associated with Biological Aggressiveness and Poor Prognosis in Patients with Bladder Cancer Who Underwent Radical Cystectomy |
| title_full_unstemmed | Expression of S100A16 Is Associated with Biological Aggressiveness and Poor Prognosis in Patients with Bladder Cancer Who Underwent Radical Cystectomy |
| title_short | Expression of S100A16 Is Associated with Biological Aggressiveness and Poor Prognosis in Patients with Bladder Cancer Who Underwent Radical Cystectomy |
| title_sort | expression of s100a16 is associated with biological aggressiveness and poor prognosis in patients with bladder cancer who underwent radical cystectomy |
| topic | bladder cancer cystectomy S100A16 protein AHNAK nucleoprotein 2 urothelial carcinoma immunohistochemistry |
| url | https://www.mdpi.com/1422-0067/24/19/14536 |
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