Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy
Highlights CD40 expression correlates with the type I anti-tumor response and better survival. Pan-cancer bioinformatics characterization reveals reduced CD40 expression in 11 cancer types, including RAS mut melanoma compared to nevi. RAS mutation correlates with reduced CD40 expression in malignant...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12943-021-01442-3 |
| _version_ | 1818932927698829312 |
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| author | Chi Yan Ann Richmond |
| author_facet | Chi Yan Ann Richmond |
| author_sort | Chi Yan |
| collection | DOAJ |
| description | Highlights CD40 expression correlates with the type I anti-tumor response and better survival. Pan-cancer bioinformatics characterization reveals reduced CD40 expression in 11 cancer types, including RAS mut melanoma compared to nevi. RAS mutation correlates with reduced CD40 expression in malignant melanoma. CD40 expression is associated with better response to immune checkpoint blockade therapy in melanoma. |
| first_indexed | 2024-12-20T04:40:16Z |
| format | Article |
| id | doaj.art-fdddad8feecb4eb2b7ceb5f48135d09a |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-20T04:40:16Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-fdddad8feecb4eb2b7ceb5f48135d09a2022-12-21T19:53:09ZengBMCMolecular Cancer1476-45982021-11-012011510.1186/s12943-021-01442-3Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapyChi Yan0Ann Richmond1Tennessee Valley Healthcare System, Department of Veterans AffairsTennessee Valley Healthcare System, Department of Veterans AffairsHighlights CD40 expression correlates with the type I anti-tumor response and better survival. Pan-cancer bioinformatics characterization reveals reduced CD40 expression in 11 cancer types, including RAS mut melanoma compared to nevi. RAS mutation correlates with reduced CD40 expression in malignant melanoma. CD40 expression is associated with better response to immune checkpoint blockade therapy in melanoma.https://doi.org/10.1186/s12943-021-01442-3CD40CancerNeviMelanomaPD-1/PD-L1CTLA4 |
| spellingShingle | Chi Yan Ann Richmond Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy Molecular Cancer CD40 Cancer Nevi Melanoma PD-1/PD-L1 CTLA4 |
| title | Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy |
| title_full | Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy |
| title_fullStr | Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy |
| title_full_unstemmed | Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy |
| title_short | Hiding in the dark: pan-cancer characterization of expression and clinical relevance of CD40 to immune checkpoint blockade therapy |
| title_sort | hiding in the dark pan cancer characterization of expression and clinical relevance of cd40 to immune checkpoint blockade therapy |
| topic | CD40 Cancer Nevi Melanoma PD-1/PD-L1 CTLA4 |
| url | https://doi.org/10.1186/s12943-021-01442-3 |
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