Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression
BackgroundAnxious depression (AD), which is generally recognized as a common clinical subtype of major depressive disorder (MDD), holds distinctive features compared with unanxious depression (UAD). However, the neural mechanism of AD still remains unrevealed. To give insight to it, we compared rest...
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00994/full |
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| author | Peng Zhao Peng Zhao Rui Yan Xinyi Wang Xinyi Wang Jiting Geng Jiting Geng Mohammad Ridwan Chattun Qiang Wang Qiang Wang Zhijian Yao Zhijian Yao Qing Lu Qing Lu |
| author_facet | Peng Zhao Peng Zhao Rui Yan Xinyi Wang Xinyi Wang Jiting Geng Jiting Geng Mohammad Ridwan Chattun Qiang Wang Qiang Wang Zhijian Yao Zhijian Yao Qing Lu Qing Lu |
| author_sort | Peng Zhao |
| collection | DOAJ |
| description | BackgroundAnxious depression (AD), which is generally recognized as a common clinical subtype of major depressive disorder (MDD), holds distinctive features compared with unanxious depression (UAD). However, the neural mechanism of AD still remains unrevealed. To give insight to it, we compared resting-state functional magnetic resonance amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) between AD and UAD patients.MethodThe data were collected from 60 AD patients, 38 UAD patients, and 60 matched healthy controls. The ALFF and seed-based FC were examined. Pearson correlations were computed between ALFF/FC and clinical measures.ResultsIn Comparison with the UAD group, the ALFF value of the right orbital part of middle frontal gyrus (RO-MFG) decreased in AD group. Specifically, the ALFF values of the RO-MFG were negatively correlated with retardation factor scores in AD group (r = -0.376, p = 0.003).ConclusionsAD patients exhibited disturbed intrinsic brain function compared with UAD patients. The decreased activity of the RO-MFG is indicative of the alterations involved in the neural basis of AD. |
| first_indexed | 2024-12-11T15:28:40Z |
| format | Article |
| id | doaj.art-fdddf94b2fb14dc2b9548232562a2e1c |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-11T15:28:40Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-fdddf94b2fb14dc2b9548232562a2e1c2022-12-22T01:00:08ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-01-011010.3389/fpsyt.2019.00994490296Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious DepressionPeng Zhao0Peng Zhao1Rui Yan2Xinyi Wang3Xinyi Wang4Jiting Geng5Jiting Geng6Mohammad Ridwan Chattun7Qiang Wang8Qiang Wang9Zhijian Yao10Zhijian Yao11Qing Lu12Qing Lu13Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaSchool of Biological Sciences & Medical Engineering, Southeast University, Nanjing, ChinaChild Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, Hangzhou Seventh People's Hospital, Hangzhou, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Medical Psychology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, ChinaNanjing Brain Hospital, Medical School of Nanjing University, Nanjing, ChinaSchool of Biological Sciences & Medical Engineering, Southeast University, Nanjing, ChinaChild Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing, ChinaBackgroundAnxious depression (AD), which is generally recognized as a common clinical subtype of major depressive disorder (MDD), holds distinctive features compared with unanxious depression (UAD). However, the neural mechanism of AD still remains unrevealed. To give insight to it, we compared resting-state functional magnetic resonance amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) between AD and UAD patients.MethodThe data were collected from 60 AD patients, 38 UAD patients, and 60 matched healthy controls. The ALFF and seed-based FC were examined. Pearson correlations were computed between ALFF/FC and clinical measures.ResultsIn Comparison with the UAD group, the ALFF value of the right orbital part of middle frontal gyrus (RO-MFG) decreased in AD group. Specifically, the ALFF values of the RO-MFG were negatively correlated with retardation factor scores in AD group (r = -0.376, p = 0.003).ConclusionsAD patients exhibited disturbed intrinsic brain function compared with UAD patients. The decreased activity of the RO-MFG is indicative of the alterations involved in the neural basis of AD.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00994/fullanxious depressionresting-state functional magnetic resonanceamplitude of low-frequency fluctuationfunctional connectivityright orbital part of middle frontal gyrus |
| spellingShingle | Peng Zhao Peng Zhao Rui Yan Xinyi Wang Xinyi Wang Jiting Geng Jiting Geng Mohammad Ridwan Chattun Qiang Wang Qiang Wang Zhijian Yao Zhijian Yao Qing Lu Qing Lu Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression Frontiers in Psychiatry anxious depression resting-state functional magnetic resonance amplitude of low-frequency fluctuation functional connectivity right orbital part of middle frontal gyrus |
| title | Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression |
| title_full | Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression |
| title_fullStr | Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression |
| title_full_unstemmed | Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression |
| title_short | Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression |
| title_sort | reduced resting state neural activity in the right orbital part of middle frontal gyrus in anxious depression |
| topic | anxious depression resting-state functional magnetic resonance amplitude of low-frequency fluctuation functional connectivity right orbital part of middle frontal gyrus |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00994/full |
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