Antimicrobial treatment of Acinetobacter neuii invasive infections: A systematic review
Aims: The objectives of this study were to find out whether and to what extent Actinomyces neuii is pathogenic to humans in terms of causing invasive infections and to ascertain the most appropriate and effective antibiotic therapy against this bacterium. Material and method: This study was designed...
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| Format: | Article |
| Language: | English |
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Medicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društva
2020-01-01
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| Series: | Praxis Medica |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0350-8773/2020/0350-87732003025M.pdf |
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| author | Milentijević Milica N. Katanić Nataša Aritonović-Pribaković Jelena Kočović Aleksandar G. Milosavljević Jovana Z. Milosavljević Miloš N. Stefanović Srđan M. Ivković Đorđe |
| author_facet | Milentijević Milica N. Katanić Nataša Aritonović-Pribaković Jelena Kočović Aleksandar G. Milosavljević Jovana Z. Milosavljević Miloš N. Stefanović Srđan M. Ivković Đorđe |
| author_sort | Milentijević Milica N. |
| collection | DOAJ |
| description | Aims: The objectives of this study were to find out whether and to what extent Actinomyces neuii is pathogenic to humans in terms of causing invasive infections and to ascertain the most appropriate and effective antibiotic therapy against this bacterium. Material and method: This study was designed as a systematic review article. MEDLINE, Google Scholar, SCIndex, Cochrane database of published clinical trials - Central and Clinicaltrials.gov databases were systematically searched for primary case reports or case series describing invasive infection with Actinomyces neuii. Results: A literature search identified 23 studies that met the inclusion criteria, describing cases of patients with an invasive infection caused by Actinomyces neuii. It was found that A. neuii could cause endocarditis, endophthalmitis, osteomyelitis, pleural empyema, soft tissue abscesses, neonatal sepsis, ventriculoperitoneal shunt infections and periprosthetic tissue infections. The most prescribed antibiotics for the treatment of Actinomyces neuii infections were amoxicillin and vancomycin (n = 10; 12.3%), followed by penicillin (n =9; 11.1%), gentamicin (n = 6; 7.4%), ampicillin (n = 5; 6.2%) and ceftazidime (n = 4; 4.9%). Antibiotic treatment of infections caused by A. neuii was followed by clinical improvement or complete cure of all patients, with no recorded deaths. Conclusion: A. neuii has a relevant pathogenic potential to cause invasive infections of various organs and tissues, especially in immunocompromised individuals of any age. For the treatment of mild infections caused by this bacterium, the antibiotics of choice are penicillin or amoxicillin, while vancomycin should be used to treat severe infections caused by Actinomyces neuii. |
| first_indexed | 2024-12-19T12:05:51Z |
| format | Article |
| id | doaj.art-fdde127c495b464196bcd8af328bc852 |
| institution | Directory Open Access Journal |
| issn | 0350-8773 2560-3310 |
| language | English |
| last_indexed | 2024-12-19T12:05:51Z |
| publishDate | 2020-01-01 |
| publisher | Medicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društva |
| record_format | Article |
| series | Praxis Medica |
| spelling | doaj.art-fdde127c495b464196bcd8af328bc8522022-12-21T20:22:22ZengMedicinski fakultet Priština, Društvo lekara Kosova i Metohije Srpskog lekarskog društvaPraxis Medica0350-87732560-33102020-01-01493-4253210.5937/pramed2004025M0350-87732003025MAntimicrobial treatment of Acinetobacter neuii invasive infections: A systematic reviewMilentijević Milica N.0Katanić Nataša1Aritonović-Pribaković Jelena2https://orcid.org/0000-0001-7203-4857Kočović Aleksandar G.3Milosavljević Jovana Z.4Milosavljević Miloš N.5https://orcid.org/0000-0002-1786-1507Stefanović Srđan M.6https://orcid.org/0000-0003-2206-2037Ivković Đorđe7Univerzitet u Prištini, Medicinski fakultet, Katedra za infektivne bolesti , SerbiaUniverzitet u Prištini, Medicinski fakultet, Katedra za infektivne bolesti , SerbiaUniverzitet u Prištini, Medicinski fakultet, Katedra za infektivne bolesti , SerbiaUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Katedra za farmaciju, SerbiaUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Katedra za anatomiju, SerbiaUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Katedra za farmakologiju i toksikologiju, SerbiaUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Katedra za farmaciju, SerbiaUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Katedra za farmaciju, SerbiaAims: The objectives of this study were to find out whether and to what extent Actinomyces neuii is pathogenic to humans in terms of causing invasive infections and to ascertain the most appropriate and effective antibiotic therapy against this bacterium. Material and method: This study was designed as a systematic review article. MEDLINE, Google Scholar, SCIndex, Cochrane database of published clinical trials - Central and Clinicaltrials.gov databases were systematically searched for primary case reports or case series describing invasive infection with Actinomyces neuii. Results: A literature search identified 23 studies that met the inclusion criteria, describing cases of patients with an invasive infection caused by Actinomyces neuii. It was found that A. neuii could cause endocarditis, endophthalmitis, osteomyelitis, pleural empyema, soft tissue abscesses, neonatal sepsis, ventriculoperitoneal shunt infections and periprosthetic tissue infections. The most prescribed antibiotics for the treatment of Actinomyces neuii infections were amoxicillin and vancomycin (n = 10; 12.3%), followed by penicillin (n =9; 11.1%), gentamicin (n = 6; 7.4%), ampicillin (n = 5; 6.2%) and ceftazidime (n = 4; 4.9%). Antibiotic treatment of infections caused by A. neuii was followed by clinical improvement or complete cure of all patients, with no recorded deaths. Conclusion: A. neuii has a relevant pathogenic potential to cause invasive infections of various organs and tissues, especially in immunocompromised individuals of any age. For the treatment of mild infections caused by this bacterium, the antibiotics of choice are penicillin or amoxicillin, while vancomycin should be used to treat severe infections caused by Actinomyces neuii.https://scindeks-clanci.ceon.rs/data/pdf/0350-8773/2020/0350-87732003025M.pdfactinomyces neuiiinvasive infectionsantibioticstherapysystematic review |
| spellingShingle | Milentijević Milica N. Katanić Nataša Aritonović-Pribaković Jelena Kočović Aleksandar G. Milosavljević Jovana Z. Milosavljević Miloš N. Stefanović Srđan M. Ivković Đorđe Antimicrobial treatment of Acinetobacter neuii invasive infections: A systematic review Praxis Medica actinomyces neuii invasive infections antibiotics therapy systematic review |
| title | Antimicrobial treatment of Acinetobacter neuii invasive infections: A systematic review |
| title_full | Antimicrobial treatment of Acinetobacter neuii invasive infections: A systematic review |
| title_fullStr | Antimicrobial treatment of Acinetobacter neuii invasive infections: A systematic review |
| title_full_unstemmed | Antimicrobial treatment of Acinetobacter neuii invasive infections: A systematic review |
| title_short | Antimicrobial treatment of Acinetobacter neuii invasive infections: A systematic review |
| title_sort | antimicrobial treatment of acinetobacter neuii invasive infections a systematic review |
| topic | actinomyces neuii invasive infections antibiotics therapy systematic review |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0350-8773/2020/0350-87732003025M.pdf |
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