Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice

Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice

The sex and APOE4 genotype are significant risk factors for Alzheimer’s disease (AD); however, the mechanism(s) responsible for this interaction are still a matter of debate. Here, we assess the responses of mixed-sex and sex-specific APOE3 and APOE4 primary microglia (PMG) to lipopolysaccharide and...

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Bibliographic Details
Main Authors: Isha Mhatre-Winters, Aseel Eid, Yoonhee Han, Kim Tieu, Jason R. Richardson
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
APOE
neuroinflammation
microglia
Alzheimer’s disease
sex
cytokine
Online Access:https://www.mdpi.com/1422-0067/23/17/9829

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