Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves
The present study was undertaken to investigate the protective effect of hydroalcoholic extract of leaves of Ipomoea staphylina against carbon tertrachloride- and gentamicin-induce hepatotoxicity and nephrotoxicity in rats respectively. The extract (200 mg/kg, p.o) showed hepatoprotective activity a...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2013-05-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/14845 |
| _version_ | 1818756272997007360 |
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| author | Anupam Kanti Bag S. M. Firdous Mumtaz |
| author_facet | Anupam Kanti Bag S. M. Firdous Mumtaz |
| author_sort | Anupam Kanti Bag |
| collection | DOAJ |
| description | The present study was undertaken to investigate the protective effect of hydroalcoholic extract of leaves of Ipomoea staphylina against carbon tertrachloride- and gentamicin-induce hepatotoxicity and nephrotoxicity in rats respectively. The extract (200 mg/kg, p.o) showed hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity by significantly (p<0.001) reducing the levels of AST, ALT, ALP, total bilirubin and significantly (p<0.001) increasing the serum total protein. The extract also showed nephro-protective activity against gentamicin-induced nephrotoxicity by significantly (p<0.001) reducing the levels of blood urea, blood urea nitrogen (BUN), serum creatinine and significantly (p<0.001) increasing the serum total protein. The extract also improves the histology of the liver and kidney. The total phenolic content and the total flavonoid content of the extract were 94.59 ± 2.54 mg gallic acid equivalent/g and 44.68 ± 2.00 mg rutin equivalent/g respectively. |
| first_indexed | 2024-12-18T05:52:25Z |
| format | Article |
| id | doaj.art-fde4f8d23c464240b87fff0d4adcb432 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-18T05:52:25Z |
| publishDate | 2013-05-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-fde4f8d23c464240b87fff0d4adcb4322022-12-21T21:18:53ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882013-05-0183Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leavesAnupam Kanti Bag0S. M. Firdous Mumtaz1Department of Pharmacology, Ratnam Institute of Pharmacy, Pidathapolur Village, Muthukur SPSR Nellore, Andhra PradeshDepartment of Pharmacology, Calcutta Institute of Pharmaceutical Technology and AHS, Uluberia, Howrah 711 316, West BengalThe present study was undertaken to investigate the protective effect of hydroalcoholic extract of leaves of Ipomoea staphylina against carbon tertrachloride- and gentamicin-induce hepatotoxicity and nephrotoxicity in rats respectively. The extract (200 mg/kg, p.o) showed hepatoprotective activity against carbon tetrachloride-induced hepatotoxicity by significantly (p<0.001) reducing the levels of AST, ALT, ALP, total bilirubin and significantly (p<0.001) increasing the serum total protein. The extract also showed nephro-protective activity against gentamicin-induced nephrotoxicity by significantly (p<0.001) reducing the levels of blood urea, blood urea nitrogen (BUN), serum creatinine and significantly (p<0.001) increasing the serum total protein. The extract also improves the histology of the liver and kidney. The total phenolic content and the total flavonoid content of the extract were 94.59 ± 2.54 mg gallic acid equivalent/g and 44.68 ± 2.00 mg rutin equivalent/g respectively.https://www.banglajol.info/index.php/BJP/article/view/14845Carbon tetrachlorideGentamicinIpomoea staphylinaNephroprotectiveNephrotoxicity |
| spellingShingle | Anupam Kanti Bag S. M. Firdous Mumtaz Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves Bangladesh Journal of Pharmacology Carbon tetrachloride Gentamicin Ipomoea staphylina Nephroprotective Nephrotoxicity |
| title | Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves |
| title_full | Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves |
| title_fullStr | Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves |
| title_full_unstemmed | Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves |
| title_short | Hepatoprotective and nephroprotective activity of hydroalcoholic extract of Ipomoea staphylina leaves |
| title_sort | hepatoprotective and nephroprotective activity of hydroalcoholic extract of ipomoea staphylina leaves |
| topic | Carbon tetrachloride Gentamicin Ipomoea staphylina Nephroprotective Nephrotoxicity |
| url | https://www.banglajol.info/index.php/BJP/article/view/14845 |
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