Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida
Two new alkaloids, 9-methoxy-18,19-dehydrocamptothecin (1) and 5- hydroxymappicine-20-O-β-glucopyranoside (2a/2b as a racemic mixture), together with nine known compounds: camptothecin (3), 9-methoxy-camptothecin (4), 5-hydroxycamptothecin (5a/5b racemic mixture), 5-hydroxy-9-methoxycamptothecin...
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MDPI AG
2008-06-01
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author | Yang-Chang Wu Fang-Rong Chang Tian-Shung Wu Chi-Yu Lu Shu-Li Chen Chia-Lin Lee Chin-Chung Wu Pei-Wen Hsieh Shou-Fang Wu |
author_facet | Yang-Chang Wu Fang-Rong Chang Tian-Shung Wu Chi-Yu Lu Shu-Li Chen Chia-Lin Lee Chin-Chung Wu Pei-Wen Hsieh Shou-Fang Wu |
author_sort | Yang-Chang Wu |
collection | DOAJ |
description | Two new alkaloids, 9-methoxy-18,19-dehydrocamptothecin (1) and 5- hydroxymappicine-20-O-β-glucopyranoside (2a/2b as a racemic mixture), together with nine known compounds: camptothecin (3), 9-methoxy-camptothecin (4), 5-hydroxycamptothecin (5a/5b racemic mixture), 5-hydroxy-9-methoxycamptothecin (6a/6b racemic mixture), diosmetin (7), apigenin (8), apigenin-7-O-glucopyranoside (9), rosin (cinnamyl- O-β-D-glucopyranoside) (10) and amarantholidoside IV (11) were isolated from the immature seeds of Nothapodytes foetida (Wight) Sleumer. The structures were elucidated by spectroscopic analyses. In the present research, compounds 1, 3, 4, 5a/5b and 6a/6b, also showed in vitro cytotoxicity against six cancer cell lines (HepG2, Hep3B, MDA-MB- 231, MCF-7, A549, and Ca9-22). Among them, compound 1 exhibited significant cytotoxicity against these cancer cell lines, with IC50 of 0.24-6.57 μM. Furthermore, HPLC profiles were developed for qualitative and quantitative analysis of these active constituents in different parts of this plant, including mature and immature seeds, leaves, stems and roots. The results revealed that compounds 3 and 4 have the highest concentrations, which are found in the roots part of the plant. |
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language | English |
last_indexed | 2024-04-12T20:05:12Z |
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spelling | doaj.art-fde5bc8ca82544bda7932c694d03b2212022-12-22T03:18:26ZengMDPI AGMolecules1420-30492008-06-011361361137110.3390/molecules13061361Camptothecinoids from the seeds of Taiwanese Nothapodytes foetidaYang-Chang WuFang-Rong ChangTian-Shung WuChi-Yu LuShu-Li ChenChia-Lin LeeChin-Chung WuPei-Wen HsiehShou-Fang WuTwo new alkaloids, 9-methoxy-18,19-dehydrocamptothecin (1) and 5- hydroxymappicine-20-O-β-glucopyranoside (2a/2b as a racemic mixture), together with nine known compounds: camptothecin (3), 9-methoxy-camptothecin (4), 5-hydroxycamptothecin (5a/5b racemic mixture), 5-hydroxy-9-methoxycamptothecin (6a/6b racemic mixture), diosmetin (7), apigenin (8), apigenin-7-O-glucopyranoside (9), rosin (cinnamyl- O-β-D-glucopyranoside) (10) and amarantholidoside IV (11) were isolated from the immature seeds of Nothapodytes foetida (Wight) Sleumer. The structures were elucidated by spectroscopic analyses. In the present research, compounds 1, 3, 4, 5a/5b and 6a/6b, also showed in vitro cytotoxicity against six cancer cell lines (HepG2, Hep3B, MDA-MB- 231, MCF-7, A549, and Ca9-22). Among them, compound 1 exhibited significant cytotoxicity against these cancer cell lines, with IC50 of 0.24-6.57 μM. Furthermore, HPLC profiles were developed for qualitative and quantitative analysis of these active constituents in different parts of this plant, including mature and immature seeds, leaves, stems and roots. The results revealed that compounds 3 and 4 have the highest concentrations, which are found in the roots part of the plant.http://www.mdpi.com/1420-3049/13/6/1361/Nothapodytes foetida9-methoxy-1819-dehydrocamptothecin5-hydroxymappicine-mappicine-20-O-β-glucopyranosidecamptothecincytotoxicity |
spellingShingle | Yang-Chang Wu Fang-Rong Chang Tian-Shung Wu Chi-Yu Lu Shu-Li Chen Chia-Lin Lee Chin-Chung Wu Pei-Wen Hsieh Shou-Fang Wu Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida Molecules Nothapodytes foetida 9-methoxy-18 19-dehydrocamptothecin 5-hydroxymappicine-mappicine-20-O-β-glucopyranoside camptothecin cytotoxicity |
title | Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida |
title_full | Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida |
title_fullStr | Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida |
title_full_unstemmed | Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida |
title_short | Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida |
title_sort | camptothecinoids from the seeds of taiwanese nothapodytes foetida |
topic | Nothapodytes foetida 9-methoxy-18 19-dehydrocamptothecin 5-hydroxymappicine-mappicine-20-O-β-glucopyranoside camptothecin cytotoxicity |
url | http://www.mdpi.com/1420-3049/13/6/1361/ |
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