Interleukin-37 relieves PM2.5-triggered lung injury by inhibiting autophagy through the AKT/mTOR signaling pathway in vivo and in vitro

Interleukin-37 relieves PM2.5-triggered lung injury by inhibiting autophagy through the AKT/mTOR signaling pathway in vivo and in vitro

Autophagy mediates PM2.5-related lung injury (LI) and is tightly linked to inflammation and apoptosis processes. IL-37 has been demonstrated to regulate autophagy. This research aimed to examine the involvement of IL-37 in the progression of PM2.5-related LI and assess whether autophagy serves as a...

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Bibliographic Details
Main Authors: Jing Cao, Shujie Hou, Zixiao Chen, Jie Yan, Lingshan Chao, Yuxing Qian, Jingwen Li, Xixin Yan
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Interleukin (IL)-37
Lung injury
Fine particulate matter (PM2.5)
Autophagy
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323013209

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